The aim of this study was to assess the ocular manifestations of diabetes and follow-up the results of treatment. Diabetes mellitus is a major cause of blindness in the USA and the leading cause of new blindness in working-aged Americans. Diabetic retinopathy alone accounts for at least 12% of new cases of blindness each year in the USA. This study focuses on progress and challenges in basic and clinical research on the ocular complications of diabetes. DR is one of the most common causes of visual loss in adults; therefore, the earlier the diagnosis, the better the management. Vascular leakage could impair neuronal function and also vision. Early detection of DR and timely intervention can reduce the incidence of moderate visual loss and severe visual loss in PDR. Diabetes mellitus is associated with measurable adverse impact on several common and important tasks of daily living, further implicating this condition as an important public health problem deserving increased attention and resources.
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