Hanan Mohamed

Effects of Punica granatum and/ or Sitagliptin on diabetic nephropathy in male rats

• Broschiertes Buch

Produktbeschreibung

Type 2 diabetes mellitus (T2DM) represents about 90% of diabetic cases. Diabetic nephropathy is one of the most serious complications of diabetes. Sitagliptin has an important role in enhancement of the Glucagon-like peptide receptor (GLP-1R) which present in the kidneys, so it may have a role in enhancement of the kidney function in T2DM. Also, Punica granatum peels extract (PGPE) is a herb which has an anti-hyperglycemic and antioxidant activities. This study was designed to investigate the role of PGPE and/or sitagliptin on renal functions in induced diabetes. Results of the present work showed that administration of streptozotocin-nicotinamide induced oxidative stress, inflammation and hyperglycemia which play a significant role in diabetes and its complications. The improvement is due to the antidiabetic, anti-inflammatory, and antioxidative actions of sitagliptin and Punica granatum peels. The combination of Punica granatum and sitagliptin compared to monotherapy have better renoprotective effects in diabetic rats.

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Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 208
• Erscheinungstermin: 19. November 2020
• Englisch
• Abmessung: 220mm x 150mm x 13mm
• Gewicht: 328g
• ISBN-13: 9786203041064
• ISBN-10: 6203041068
• Artikelnr.: 60753952

Autorenporträt

Hanan Essam MohamedBachelorder Medizin, Bachelor der Chirurgie, Universität Mansoura(2014).Masterstudentin in Physiologie an der Al-Azhar-Universität für MädchenAktuelleStelle: Demonstratorin in der Abteilung Physiologie, Medizinische Fakultät, Helwan-Universität.