This book examines the effectiveness of internet-delivered clinical therapy for depression treatment in rural communities with a particular focus on the rural, Southern regions of the United States. Major research studies and theories in this area suggest that this would be an effective modality for treatment among patients with depression. Methods for this study included collecting research articles from Australia, Canada, and the United States for depression/mental health treatment in rural areas, comparing the results, and relating them to the rural American South. Results indicate that internet-delivered clinical therapy is a therapeutically beneficial and cost-effective treatment for depression and others related mental illnesses with over 30,000 participants studied showing significant improvement in their depressive symptoms. Interpretations and recommendations of this research for future practice in the field of psychology include increased utilization of internet-delivered clinical therapy for depression treatment in rural areas and communities in the rural South as it has the potential to reach patents who are in need of quality mental health services.