Tjitske Heida

Electric Field-Induced Effects on Neuronal Cell Biology Accompanying Dielectrophoretic Trapping

• Broschiertes Buch

Produktbeschreibung

The concept of the cultured neuron probe was induced by the possible selective stimulation of nerves for functional recovery after a neural lesion or disease. The probe consists of a micro-electrode array on top of which groups of neuronal cells are cultured. An efficient method to position groups of neuronal cells on top of the stimulation sites of the micro-electrode array is developed. With negative dielectrophoretic forces, produced by non-uniform electric fields on polarizable particles, neuronal cells are trapped. Experimental results and model simulations describe the trapping process and its effect on neuronal cell viability.

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Produktdetails

• Advances in Anatomy, Embryology and Cell Biology 173
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-540-00637-4
• Softcover reprint of the original 1st ed. 2003
• Seitenzahl: 92
• Erscheinungstermin: 23. Juni 2003
• Englisch
• Abmessung: 235mm x 155mm x 6mm
• Gewicht: 204g
• ISBN-13: 9783540006374
• ISBN-10: 3540006370
• Artikelnr.: 12147366

Autorenporträt

Tjitske Heida, University of Twente, Enschede, The Netherlands

Inhaltsangabe

1 Introduction.- 1.1 Neuro-Electronic Interfacing.- 1.2 Culturing Neuronal Cells.- 1.3 Positioning and Culturing Neuronal Cells on a Microelectrode Array.- 1.4 Dielectrophoresis.- 1.5 Scope of This Review.- 2 Dielectrophoretic Trapping of Neuronal Cells.- 2.1 Theory.- 2.2 Materials.- 2.3 Theoretical Description of Dielectrophoretic Trapping.- 2.4 Experimental Description of Dielectrophoretic Trapping.- 3 Exposing Neuronal Cells to Electric Fields.- 3.1 Theory.- 3.2 Theoretical Investigation of Induced Membrane Potentials of Neuronal Cells.- 3.3 Experimental Investigation of Neuronal Membrane Breakdown.- 4 Investigating Viability of Dielectrophoretically Trapped Neuronal Cells.- 4.1 Viability of Neuronal Cells Trapped at a High Frequency.- 4.2 Viability of Neuronal Cells Trapped at Low Frequencies.- 4.3 Recording Neuronal Activity.- 5 Summary.- References.