Emerging Cancer Therapy
Eds.: Fialho, Arsenio; Chakrabarty, Ananda
Emerging Cancer Therapy
Eds.: Fialho, Arsenio; Chakrabarty, Ananda
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Cancer therapy remains a challenge despite the huge changes and improvements we have made in the scientific and engineering tools that we use. Emerging Cancer Therapy explores the potential and actual uses of live bacteria or their products in the treatment of cancer. Providing a state-of-the-art overview of this field, this book breaks new ground in emerging cancer treatment modalities. Microbes that are currently and can potentially be used therapeutically and their products are reviewed in detail, and studies involving clinical trials and evaluation with these anticancer agents are addressed.…mehr
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Cancer therapy remains a challenge despite the huge changes and improvements we have made in the scientific and engineering tools that we use. Emerging Cancer Therapy explores the potential and actual uses of live bacteria or their products in the treatment of cancer. Providing a state-of-the-art overview of this field, this book breaks new ground in emerging cancer treatment modalities. Microbes that are currently and can potentially be used therapeutically and their products are reviewed in detail, and studies involving clinical trials and evaluation with these anticancer agents are addressed.
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Produktdetails
- Produktdetails
- Wiley Series on Biotechnology
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14544467000
- 1. Auflage
- Seitenzahl: 448
- Erscheinungstermin: 9. August 2010
- Englisch
- Abmessung: 240mm x 161mm x 29mm
- Gewicht: 815g
- ISBN-13: 9780470444672
- ISBN-10: 0470444673
- Artikelnr.: 30589923
- Wiley Series on Biotechnology
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14544467000
- 1. Auflage
- Seitenzahl: 448
- Erscheinungstermin: 9. August 2010
- Englisch
- Abmessung: 240mm x 161mm x 29mm
- Gewicht: 815g
- ISBN-13: 9780470444672
- ISBN-10: 0470444673
- Artikelnr.: 30589923
ARSÉNIO FIALHO, PHD, is Associate Professor in the Department of Chemical and Biological Engineering and Principal Investigator for the Institute of Biotechnology and Bioengineering in the Instituto Superior Técnico at the Universidade Técnica de Lisboa, Portugal. His current scientific interests are focused on the study of bacterial proteins, such as azurin and Laz, as novel multi-targeted drug candidates with anticancer activities. He is the author or coauthor of more than fifty papers in peer-reviewed scientific journals and, during the last four years, became the holder of five U.S. patents. Dr. Fialho teaches courses in biochemistry, molecular biology, and bioinformatics. ANANDA CHAKRABARTY, PHD, is Distinguished University Professor in the Department of Microbiology and Immunology at the University of Illinois College of Medicine at Chicago. In addition to more than 250 research publications, he has secured nine U.S. patents during the last four years on azurin and Laz, two bacterial proteins with anticancer, anti-viral and anti-parasitic activities. He also is the recipient of a patent on the first life form, a genetically manipulated pseudomonad designed to degrade multiple hydrocarbons present in crude oil, as decided by the U.S. Supreme Court in 1980 in the celebrated court case Diamond v. Chakrabarty.
Preface ix
Contributors xi
Part I Live/Attenuated Bacteria and Viruses as Anticancer Agents 1
1 Salmonella Typhimurium Mutants Selected to Grow Only in Tumors to
Eradicate Them in Nude Mouse Models 3
Robert M. Hoffman
2 The Use of Living Listeria Monocytogenes as an Active Immunotherapy for
the Treatment of Cancer 13
John Rothman, Anu Wallecha, Paulo Cesar Maciag, Sandra Rivera, Vafa
Shahabi, and Yvonne Paterson
3 Bacillus Calmette-Guerin (BCG) for Urothelial Carcinoma of the Bladder 49
Timothy P. Kresowik and Thomas S. Griffith
4 Live Clostridia: A Powerful Tool in Tumor Biotherapy 71
Lieve Van Mellaert, Ming Q Wei, and Jozef Anné
5 Bifi dobacterium as a Delivery System of Functional Genes for Cancer Gene
Therapy 99
Geng-Feng Fu, Yan Yin, Bi Hu, and Gen-Xing Xu
6 Replication-Selective Viruses for the Treatment of Cancer 119
Padma Sampath and Steve H. Thorne
7 Engineering Herpes Simplex Virus for Cancer Oncolytic Virotherapy 141
Jason S. Buhrman, Tooba A. Cheema, and Giulia Fulci
Part II Bacterial Products as Anticancer Agents 179
8 Promiscuous Anticancer Drugs from Pathogenic Bacteria: Rational Versus
Intelligent Drug Design 181
Arsénio M. Fialho and Ananda M. Chakrabarty
9 Arginine Deiminase and Cancer Therapy 199
Lynn Feun, M. Tien Kuo, Ming You, Chung Jing Wu, Medhi Wangpaichitr, and
Niramol Savaraj
10 Cytosine Deaminase/5-Fluorocytosine Molecular Cancer Chemotherapy 219
Sergey A. Kaliberov and Donald J. Buchsbaum
11 Bacterial Proteins against Metastasis 243
Anna Maria Elisabeth Walenkamp
12 Pseudomonas Exotoxin A-Based Immunotoxins for Targeted Cancer Therapy
269
Philipp Wolf and Ursula Elsässer-Beile
13 Denileukin Diftitox in Novel Cancer Therapy 289
Lin-Chi Chen and Nam H. Dang
14 The Application of Cationic Antimicrobial Peptides in Cancer Treatment:
Laboratory Investigations and Clinical Potential 309
Ashley L. Hilchie and David W. Hoskin
15 Prodiginines and Their Potential Utility as Proapoptotic Anticancer
Agents 333
Neil R. Williamson, Suresh Chawrai, Finian J. Leeper, and George P.C.
Salmond
16 Farnesyltransferase Inhibitors of Microbial Origins in Cancer Therapy
367
Jingxuan Pan and Sai-Ching Jim Yeung
17 The Use of RNA and CpG DNA as Nucleic Acid-Based Therapeutics 379
Jörg Vollmer
Part III Patents On Bacteria/Bacterial Products as Anticancer Agents 403
18 The Role and Importance of Intellectual Property Generation and
Protection in Drug Development 405
Arsénio M. Fialho and Ananda M. Chakrabarty
Index 421
Contributors xi
Part I Live/Attenuated Bacteria and Viruses as Anticancer Agents 1
1 Salmonella Typhimurium Mutants Selected to Grow Only in Tumors to
Eradicate Them in Nude Mouse Models 3
Robert M. Hoffman
2 The Use of Living Listeria Monocytogenes as an Active Immunotherapy for
the Treatment of Cancer 13
John Rothman, Anu Wallecha, Paulo Cesar Maciag, Sandra Rivera, Vafa
Shahabi, and Yvonne Paterson
3 Bacillus Calmette-Guerin (BCG) for Urothelial Carcinoma of the Bladder 49
Timothy P. Kresowik and Thomas S. Griffith
4 Live Clostridia: A Powerful Tool in Tumor Biotherapy 71
Lieve Van Mellaert, Ming Q Wei, and Jozef Anné
5 Bifi dobacterium as a Delivery System of Functional Genes for Cancer Gene
Therapy 99
Geng-Feng Fu, Yan Yin, Bi Hu, and Gen-Xing Xu
6 Replication-Selective Viruses for the Treatment of Cancer 119
Padma Sampath and Steve H. Thorne
7 Engineering Herpes Simplex Virus for Cancer Oncolytic Virotherapy 141
Jason S. Buhrman, Tooba A. Cheema, and Giulia Fulci
Part II Bacterial Products as Anticancer Agents 179
8 Promiscuous Anticancer Drugs from Pathogenic Bacteria: Rational Versus
Intelligent Drug Design 181
Arsénio M. Fialho and Ananda M. Chakrabarty
9 Arginine Deiminase and Cancer Therapy 199
Lynn Feun, M. Tien Kuo, Ming You, Chung Jing Wu, Medhi Wangpaichitr, and
Niramol Savaraj
10 Cytosine Deaminase/5-Fluorocytosine Molecular Cancer Chemotherapy 219
Sergey A. Kaliberov and Donald J. Buchsbaum
11 Bacterial Proteins against Metastasis 243
Anna Maria Elisabeth Walenkamp
12 Pseudomonas Exotoxin A-Based Immunotoxins for Targeted Cancer Therapy
269
Philipp Wolf and Ursula Elsässer-Beile
13 Denileukin Diftitox in Novel Cancer Therapy 289
Lin-Chi Chen and Nam H. Dang
14 The Application of Cationic Antimicrobial Peptides in Cancer Treatment:
Laboratory Investigations and Clinical Potential 309
Ashley L. Hilchie and David W. Hoskin
15 Prodiginines and Their Potential Utility as Proapoptotic Anticancer
Agents 333
Neil R. Williamson, Suresh Chawrai, Finian J. Leeper, and George P.C.
Salmond
16 Farnesyltransferase Inhibitors of Microbial Origins in Cancer Therapy
367
Jingxuan Pan and Sai-Ching Jim Yeung
17 The Use of RNA and CpG DNA as Nucleic Acid-Based Therapeutics 379
Jörg Vollmer
Part III Patents On Bacteria/Bacterial Products as Anticancer Agents 403
18 The Role and Importance of Intellectual Property Generation and
Protection in Drug Development 405
Arsénio M. Fialho and Ananda M. Chakrabarty
Index 421
Preface ix
Contributors xi
Part I Live/Attenuated Bacteria and Viruses as Anticancer Agents 1
1 Salmonella Typhimurium Mutants Selected to Grow Only in Tumors to
Eradicate Them in Nude Mouse Models 3
Robert M. Hoffman
2 The Use of Living Listeria Monocytogenes as an Active Immunotherapy for
the Treatment of Cancer 13
John Rothman, Anu Wallecha, Paulo Cesar Maciag, Sandra Rivera, Vafa
Shahabi, and Yvonne Paterson
3 Bacillus Calmette-Guerin (BCG) for Urothelial Carcinoma of the Bladder 49
Timothy P. Kresowik and Thomas S. Griffith
4 Live Clostridia: A Powerful Tool in Tumor Biotherapy 71
Lieve Van Mellaert, Ming Q Wei, and Jozef Anné
5 Bifi dobacterium as a Delivery System of Functional Genes for Cancer Gene
Therapy 99
Geng-Feng Fu, Yan Yin, Bi Hu, and Gen-Xing Xu
6 Replication-Selective Viruses for the Treatment of Cancer 119
Padma Sampath and Steve H. Thorne
7 Engineering Herpes Simplex Virus for Cancer Oncolytic Virotherapy 141
Jason S. Buhrman, Tooba A. Cheema, and Giulia Fulci
Part II Bacterial Products as Anticancer Agents 179
8 Promiscuous Anticancer Drugs from Pathogenic Bacteria: Rational Versus
Intelligent Drug Design 181
Arsénio M. Fialho and Ananda M. Chakrabarty
9 Arginine Deiminase and Cancer Therapy 199
Lynn Feun, M. Tien Kuo, Ming You, Chung Jing Wu, Medhi Wangpaichitr, and
Niramol Savaraj
10 Cytosine Deaminase/5-Fluorocytosine Molecular Cancer Chemotherapy 219
Sergey A. Kaliberov and Donald J. Buchsbaum
11 Bacterial Proteins against Metastasis 243
Anna Maria Elisabeth Walenkamp
12 Pseudomonas Exotoxin A-Based Immunotoxins for Targeted Cancer Therapy
269
Philipp Wolf and Ursula Elsässer-Beile
13 Denileukin Diftitox in Novel Cancer Therapy 289
Lin-Chi Chen and Nam H. Dang
14 The Application of Cationic Antimicrobial Peptides in Cancer Treatment:
Laboratory Investigations and Clinical Potential 309
Ashley L. Hilchie and David W. Hoskin
15 Prodiginines and Their Potential Utility as Proapoptotic Anticancer
Agents 333
Neil R. Williamson, Suresh Chawrai, Finian J. Leeper, and George P.C.
Salmond
16 Farnesyltransferase Inhibitors of Microbial Origins in Cancer Therapy
367
Jingxuan Pan and Sai-Ching Jim Yeung
17 The Use of RNA and CpG DNA as Nucleic Acid-Based Therapeutics 379
Jörg Vollmer
Part III Patents On Bacteria/Bacterial Products as Anticancer Agents 403
18 The Role and Importance of Intellectual Property Generation and
Protection in Drug Development 405
Arsénio M. Fialho and Ananda M. Chakrabarty
Index 421
Contributors xi
Part I Live/Attenuated Bacteria and Viruses as Anticancer Agents 1
1 Salmonella Typhimurium Mutants Selected to Grow Only in Tumors to
Eradicate Them in Nude Mouse Models 3
Robert M. Hoffman
2 The Use of Living Listeria Monocytogenes as an Active Immunotherapy for
the Treatment of Cancer 13
John Rothman, Anu Wallecha, Paulo Cesar Maciag, Sandra Rivera, Vafa
Shahabi, and Yvonne Paterson
3 Bacillus Calmette-Guerin (BCG) for Urothelial Carcinoma of the Bladder 49
Timothy P. Kresowik and Thomas S. Griffith
4 Live Clostridia: A Powerful Tool in Tumor Biotherapy 71
Lieve Van Mellaert, Ming Q Wei, and Jozef Anné
5 Bifi dobacterium as a Delivery System of Functional Genes for Cancer Gene
Therapy 99
Geng-Feng Fu, Yan Yin, Bi Hu, and Gen-Xing Xu
6 Replication-Selective Viruses for the Treatment of Cancer 119
Padma Sampath and Steve H. Thorne
7 Engineering Herpes Simplex Virus for Cancer Oncolytic Virotherapy 141
Jason S. Buhrman, Tooba A. Cheema, and Giulia Fulci
Part II Bacterial Products as Anticancer Agents 179
8 Promiscuous Anticancer Drugs from Pathogenic Bacteria: Rational Versus
Intelligent Drug Design 181
Arsénio M. Fialho and Ananda M. Chakrabarty
9 Arginine Deiminase and Cancer Therapy 199
Lynn Feun, M. Tien Kuo, Ming You, Chung Jing Wu, Medhi Wangpaichitr, and
Niramol Savaraj
10 Cytosine Deaminase/5-Fluorocytosine Molecular Cancer Chemotherapy 219
Sergey A. Kaliberov and Donald J. Buchsbaum
11 Bacterial Proteins against Metastasis 243
Anna Maria Elisabeth Walenkamp
12 Pseudomonas Exotoxin A-Based Immunotoxins for Targeted Cancer Therapy
269
Philipp Wolf and Ursula Elsässer-Beile
13 Denileukin Diftitox in Novel Cancer Therapy 289
Lin-Chi Chen and Nam H. Dang
14 The Application of Cationic Antimicrobial Peptides in Cancer Treatment:
Laboratory Investigations and Clinical Potential 309
Ashley L. Hilchie and David W. Hoskin
15 Prodiginines and Their Potential Utility as Proapoptotic Anticancer
Agents 333
Neil R. Williamson, Suresh Chawrai, Finian J. Leeper, and George P.C.
Salmond
16 Farnesyltransferase Inhibitors of Microbial Origins in Cancer Therapy
367
Jingxuan Pan and Sai-Ching Jim Yeung
17 The Use of RNA and CpG DNA as Nucleic Acid-Based Therapeutics 379
Jörg Vollmer
Part III Patents On Bacteria/Bacterial Products as Anticancer Agents 403
18 The Role and Importance of Intellectual Property Generation and
Protection in Drug Development 405
Arsénio M. Fialho and Ananda M. Chakrabarty
Index 421