During spreading of Diseases, Nutritional immune supplements help to increases the general immunity of a population at short duration. In this immunotherapy various natural products such as immunostimulants, probiotics, micronutrients, vaccines, antimicrobial proteins, Herbal products, etc. support to enhances the functions of immune system. However, vaccines give specific protection against particular infections. Nowadays DNA with suitable antigenic proteins are used in vaccine development. Additionally, Heat Stress protein, probiotics suitable bioadjuvents and bio preservatives are also added for enhances immunity and increase the efficacy of vaccine. So Based on the continuous experimental trials, will develop new vaccines against any type of infectious diseases during short period with minimum facilities and save our Human and Animal population