Encyclopedia of Drug Metabolism and Interactions, 6 Volume Set

Herausgegeben von Lyubimov, Alexander V.

• Gebundenes Buch

Produktbeschreibung

This multi-volume, state-of-the-art encyclopedia discusses all preclinical, clinical, toxicological, regulatory and marketing perspectives of drug metabolism and interactions. Methods and detailed protocols describing how to perform studies of metabolism and drug interactions are presented in one of the volumes. All aspects of drug metabolism and interactions in silico, in laboratory animals and in humans, are backed with a range of examples. This reference is essential for researchers interested in all aspects of drug development, and chemists, pharmacologists, pharmaceutical specialists, toxicologists, molecular toxicologists, and clinicians including practitioners and physicians.

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The Encyclopedia of Drug Metabolism and Interactions provides essential support during all phases of drug development, from drug design to drug action and interaction in patients.

This multivolume work covers both preclinical and clinical aspects of drug metabolism and interactions. It also provides a wealth of toxicological, regulatory, and marketing information, all written by leading international experts in the field. Using this reference you'll discover:

Enzymes that can be inhibited or induced and their impact on drug toxicity and altered response in both animal and human models
Effect of genetic differences and non-genetic factors on drug metabolism
Balance among drug metabolism, its inactivation/activation, and its potential toxicity
Examples demonstrating all aspects of drug metabolism and interactions in silico, in laboratory animals, and in humans
Methods and detailed protocols enabling you to perform seamless studies of metabolism and drug interactions

This reference is essential for researchers interested in all aspects of drug development, and chemists, pharmacologists, pharmaceutical specialists, toxicologists, molecular toxicologists, and clinicians, including practitioners and physicians.

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The Encyclopedia of Drug Metabolism and Interactions is available online now. For further information visit wileyonlinelibrary.com/ref/lyubimov

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 4736
• Erscheinungstermin: 5. November 2012
• Englisch
• Abmessung: 420mm x 276mm x 144mm
• Gewicht: 9604g
• ISBN-13: 9780470450154
• ISBN-10: 0470450150
• Artikelnr.: 33877056

Autorenporträt

ALEXANDER V. LYUBIMOV, MD, PhD, DABT, is Director of the Toxicology Research Laboratory and Associate Professor of Pharmacology at the University of Illinois at Chicago. He has more than thirty years of experience in the fields of toxicology, bioanalytical chemistry, and drug efficacy. He has presented his research results at more than fifty national and international scientific conferences. In addition, he has published more than 140 scientific publications in peer-reviewed journals, books, and conference proceedings. Dr. Lyubimov has served as chair or president of several international conferences, including "Frontiers of Pharmacology and Toxicology," which he also organized.

Inhaltsangabe

VOLUME I Part 1: Basics Overview of Drug Metabolism Chapter 1 Review of
Drug Metabolism in Drug Discovery and Development Chapter 2 Reactions and
Models of Drug Metabolism Chapter 3 Enzyme kinetics of drug metabolism
reactions and drug-drug interactions Chapter 4 Developmental changes in
drug metabolizing enzymes Chapter 5 Species differences in drug
metabolizing enzymes Part II: Enzyme systems involved in drug metabolism
and interactions in animals and humans Chapter 6 Structure and function of
cytochrome P450 enzymes Chapter 7 Mechanism of cytochrome P450 mediated
reactions Chapter 8 Transcriptional regulation of cytochrome P450 enzymes
Chapter 9 Cytochrome P450 polymorphisms Chapter 10 Flavin monooxygenase
Chapter 11 Molybdenum containing enzymes Chapter 12 Amine odidases and
reductases Chapter 13 Epoxide hydrolase Chapter 14 Esterases and amidases
Chapter 15 UDP- glucuronosyltransferases Chapter 16 Sulfotransferases
Chapter 17 Glutathione S- transferases Chapter 18 Amino acid conjugation
VOLUME II Part III: General principals of ADME. Drug transporters and other
mechanisms of transport Chapter 1 Introduction to ADME. Overview Chapter 2
Anatomical and Physiological Parameters that Influence Gastrointestinal
Absorption Chapter 3 Absorption of drugs into the body Chapter 4 General
principles of drug distribution Chapter 5 ABC drug transporters and their
impact on drug disposition/drug sensitivity and resistance Chapter 6 SLC
family transporters Chapter 7 General principles of drug metabolism Chapter
8 Systems where drug metabolism occurs Chapter 9 Mass balance studies in
animals and humans Chapter 10 Bioavailability and bioequivalence Chapter 11
Allometric scaling Chapter 12 Effect of protein binding in ADME Chapter 13
Excretion systems Chapter 14 Pharmacokinetics (PK) and toxicokinetics (TK)
Chapter 15 Experimental design/mathematical models and data
analysis/interpretation for PK /TK studies Chapter 16 Physiologically-Based
Pharmacokinetic Modeling Chapter 17 Pharmacodynamics Chapter 18
Interrelationships between Pharmacokinetics / Pharmacodynamics and
metabolism Part IV: ADME of some specific groups of drugs and delivery
systems Chapter 19 ADME of herbal and dietary constituents Chapter 20 ADME
of anticancer drugs Chapter 21 ADME of cardiovascular drugs Chapter 22 ADME
of biological drugs Chapter 23 ADME of natural toxins Chapter 24 Metabolism
and drug-drug interactions in pregnant mother/placenta/fetus VOLUME III
Part V: Drug Design and development Chapter 1 Where and when does drug
metabolism enter as a concern? Chapter 2 Challenges in frontloading
toxicity testing of anti- cancer drugs in drug discovery Chapter 3 Role of
ADME for selection of new drug candidates Chapter 4 Efficient drug
development. How to speed up the development process Chapter 5 Metabolite
profiling and identification Chapter 6 Bioactivation and oxidative stress
Chapter 7 Metabolism in drug safety evaluation Part VI: Methods and
protocols for prediction and evaluation of drug metabolism and drug
interaction studies Chapter 8 In silico models of drug metabolism and drug
interactions Chapter 9 Methods for determination of enzyme kinetics and
metabolic rates Chapter 10 Assays and microarrays for metabolic pathways
Chapter 11 Applications using Caco-2 cells and TC7 cells for drug
metabolism studies Chapter 12 In vitro liver systems to study
induction/inhibition. Prediction of in vivo metabolism and drug-drug
interactions Chapter 13 Assessing the Hepatic Disposition and Toxicity of
Xenobiotics Using Primary Hepatocytes Chapter 14 Monoclonal Antibody Based
Analyses of Human Drug Metabolism and Multifuctional Cytochromes P450
Chapter 15 Validation of precision- cut slices as a tool to study induction
of drug metabolism Chapter 16 Practical aspects of high throughput
solubility and dissolution assessment in preformulation Chapter 17
Integrated Approaches to Blood Brain Barrier and its role for drug
metabolism and interactions Chapter 18 In vivo models (not genetically
modified) Chapter 19 Using mouse knockout and transgenic models to study
metabolism VOLUME IV Part VII: Pharmacology and toxicology Chapter 1
Introduction. Overview. Role of metabolism in drug toxicity Chapter 2
Bioactivation I: Phase I (P450) Chapter 3 Bioactivation II: Phase I (non
P450) Chapter 4 Bioactivation III: Phase II Chapter 5 Covalent Binding
Chapter 6 MIST Chapter 7 Cell- based predictors for Toxicities of
Metabolites Chapter 8 Toxicogenomics Chapter 9 Metabonomics Chapter 10
Proteomics Chapter 11 Stereoselectivity in drug metabolism PART VIII:
Influence of physiological conditions, diseases, drug- food interactions,
age, sex, and other factors on drug metabolism and effect Chapter 12
Genetic influence on metabolism Chapter 13 Drug- Drug interactions 1:
Inhibition Chapter 14 Drug- Drug Interactions 2: Induction Chapter 15
Ontogeny and Metabolism Chapter 16 Natural Modulators of Human Drug
Metabolism: Dietary supplements and their Clinical Relevance (Food Effects
on Toxicity and Pharmacology) Chapter 17 Idiosyncratic drug interactions
Chapter 18 Influence of inflammatory stress on drug (or xenobiotic)
hepatotoxicity Chapter 19 Regulation of Drug-Metabolizingnzymes and
Transporters in Infection, Inflammation, and Cancer VOLUME V Part IX:
Bioanalytical methods of studying metabolism Chapter 1 Introduction.
Importance of in vivo/in vitro analytical results in drug development
Walter Chapter 2 General principles of mass spectrometry: LC-MS, LC-MS/MS,
and GC-MS Chapter 3 Electrospray and Infusion nanospray ionization Chapter
4 Emerging Atmospheric pressure ionization Chapter 5 Matrix assisted laser
desorption ionization (MALDI) Chapter 6 Ion trap and quadrupole MS Chapter
7 Hybrid LTQ- FTMS for Drug Metabolism Applications Chapter 8 Mass
Spectrometry Imaging (MSI) Chapter 9 Ion Mobility Spectrometry and High
Performance Tandem MS for metabolism studies and identification Chapter 10
Inductively coupled plasma mass spectrometry (ICP MS) for element-
containing drug metabolism analysis Chapter 11 Online Electrochemical LC-
MS Techniques for Profiling Chapter 12 NMR Chapter 13 Whole body autography
and radioactive and non- radioactive isotope assays Chapter 14 Ligand
binding assays (immunoassays) Chapter 16 Direct plasma analysis systems
Chapter 17 Analytical method development and validation in accordance to
the regulatory guidelines Chapter 18 Leveraging advances in HPLC to
maximize DMPK data quality Chapter 19 Methodologies to Increase Analytical
Throughput Chapter 20 Biomarkers to enable PK/PD Chapter 21 Bioanalytics
for Human Microdosing Chapter 22 Bioactivation and Reactive Metabolite
Assays Chapter 23 Plasma protein binding VOLUME VI Part X: Clinical aspects
of drug metabolism and interactions Chapter 1 Overview and introduction.
Role of drug metabolism and drug interactions in humans Chapter 2 Human
cytochrome P450 enzymes Chapter 3 DDI Risk Assessment and Evaluation in
Clinical Development: Interfacing Drug Metabolism and Clinical Pharmacology
Chapter 4 Current and future tools for predicting clinical drug
interactions Chapter 5 Predicting human biotransformation pathways Chapter
6 Conjugation, transport, and elimination of drugs in humans Chapter 7 Role
and clinical consequences of human UDP- Glucuronosyltransferases Chapter 8
Drug/food and drug/herb interactions Chapter 9 Effects of disease on
metabolism of drugs in humans Chapter 10 Role of Phase I metabolism in drug
activation and clinical treatment outcomes Chapter 11 Role of metabolism in
toxicity of drugs in humans Chapter 12 Idiosyncratic drug reactions and the
potential role of metabolism Part XI Metabolism of specific drug groups and
patient populations Chapter 13 Metabolism of psychotropic drugs Chapter 14
Metabolic-based consequences of polytherapy with AED Chapter 15 Oral
chemotherapeutic agents: Understanding mechanisms of action and drug
interactions Chapter 16 Drug metabolism and interactions in pediatric
patients Chapter 17 Population- based pharmacokinetic modeling and
simulation Chapter 18 Clinical Pharmacology in drug labeling. The impact of
drug metabolism and clinical pharmacology on recommended dose of drugs

Rezensionen

"This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries -- a global endeavor accomplished under the leadership of editor Alexander Lyubimov (pharmacology, The U. of Illinois, Chicago)." (Book News, 1 February 2013)

"Summing Up: Recommended. Graduate students through professionals/practitioners." (Choice, 1 March 2013)