Endocrine glands may be involved in patients with thalassemia major. In the last 20 years, new therapies have significantly improved life expectancy, while several endocrine abnormalities have been described in children, adolescents, and young adults suffering from thalassemia major. The practical objective of this book is to establish guidelines for the management of endocrine disorders underlying the various phases of thalassemic life. Internationally acknowledged experts give a state-of-the-art account of physiopathological and therapeutical approaches to endocrine disorders in thalassemia…mehr
Endocrine glands may be involved in patients with thalassemia major. In the last 20 years, new therapies have significantly improved life expectancy, while several endocrine abnormalities have been described in children, adolescents, and young adults suffering from thalassemia major. The practical objective of this book is to establish guidelines for the management of endocrine disorders underlying the various phases of thalassemic life. Internationally acknowledged experts give a state-of-the-art account of physiopathological and therapeutical approaches to endocrine disorders in thalassemia and focus on such topics as growth hormones, thyroid diseases, puberty, hypogonadism, diabetes, and bone metabolism.
Plenary Lectures.- Spontaneous Growth Hormone (GH) Secretion and Results of Therapy with GH in Thalassemic Patients.- Plasma Growth Hormone-Binding Protein and Liver Receptor in Thalassemic Patients.- Short-term Follow-up Study of Thyroid Function in Polytransfused Thalassemic Patients.- Spermatogenesis in Patients with ?-Thalassaemia major and intermedia.- Long-term Follow-up of Hypothalamic-Pituitary Axis in Thalassaemic Patients with Secondary Amenorrhoea.- Abnormal Bone Metabolism in Thalassemia.- Bone Mineral Content by Single- and Dual-Photon Absorptiometry in Thalassemic Patients.- Osteopenia in Thalassemic Patients with Primary and Secondary Amenorrhea.- Imaging, Ultrastructural Aspects, and Trace Elements in the Thalassemic Condrodystrophy.- Glucose Intolerance and Diabetes in Thalassaemia major.- Pancreatic beta-Cell Function Before and After Bone Marrow Transplantation for Thalassemia.- A Multicenter Study on Endocrine Disorders in Thalassemia-Introduction.- Endocrine Pathology in Thalassemia.- Endocrine Complications in Cyprian Thalassemic Patients.- Thalassemia and Endocrinopathies: A Multicenter Study of 3092 Patients.- Communications.- Growth in Homozygous ?-Thalassemic Patients.- Relationship Between GH Response to Stimuli, Levels of IGF-1, and Final Height.- Growth Hormone Secretion in Thalassemic Patients.- Binding of Insulin-like Growth Factor-1 to Erythrocytes in Children with Thalassemia.- Evaluation of Thyroid Function in Thalassemic Patients Undergoing Long-term Blood Transfusion and Iron-Chelation Therapy.- Pituitary-Thyroid Function in Children with ?-Thalassemia major.- Thyroid Function in Thalassemia major.- Pituitary-Gonadal Response to Short-term Pulsatile Luteinizing Hormone-Releasing Hormone Administration in Young ThalassemicPatients.- Pubertal Development in Female Thalassemics.- The Pituitary-Thyroid-Gonadal Axis in Saudi ?-Thalassaemia Patients.- Insulin-dependent Diabetes mellitus in a Group of Young People with beta-Thalassemia major.- A Transverse and Longitudinal Study of Pancreatic Function and Glucose Tolerance in Thalassemic Patients.- ?-Cell-Glucose Non-sensing in Patients with Thalassemia major and Glucose Intolerance.- Secondary Diabetes mellitus in Thalassemic Patients.- Subject-Index.
Plenary Lectures.- Spontaneous Growth Hormone (GH) Secretion and Results of Therapy with GH in Thalassemic Patients.- Plasma Growth Hormone-Binding Protein and Liver Receptor in Thalassemic Patients.- Short-term Follow-up Study of Thyroid Function in Polytransfused Thalassemic Patients.- Spermatogenesis in Patients with ?-Thalassaemia major and intermedia.- Long-term Follow-up of Hypothalamic-Pituitary Axis in Thalassaemic Patients with Secondary Amenorrhoea.- Abnormal Bone Metabolism in Thalassemia.- Bone Mineral Content by Single- and Dual-Photon Absorptiometry in Thalassemic Patients.- Osteopenia in Thalassemic Patients with Primary and Secondary Amenorrhea.- Imaging, Ultrastructural Aspects, and Trace Elements in the Thalassemic Condrodystrophy.- Glucose Intolerance and Diabetes in Thalassaemia major.- Pancreatic beta-Cell Function Before and After Bone Marrow Transplantation for Thalassemia.- A Multicenter Study on Endocrine Disorders in Thalassemia-Introduction.- Endocrine Pathology in Thalassemia.- Endocrine Complications in Cyprian Thalassemic Patients.- Thalassemia and Endocrinopathies: A Multicenter Study of 3092 Patients.- Communications.- Growth in Homozygous ?-Thalassemic Patients.- Relationship Between GH Response to Stimuli, Levels of IGF-1, and Final Height.- Growth Hormone Secretion in Thalassemic Patients.- Binding of Insulin-like Growth Factor-1 to Erythrocytes in Children with Thalassemia.- Evaluation of Thyroid Function in Thalassemic Patients Undergoing Long-term Blood Transfusion and Iron-Chelation Therapy.- Pituitary-Thyroid Function in Children with ?-Thalassemia major.- Thyroid Function in Thalassemia major.- Pituitary-Gonadal Response to Short-term Pulsatile Luteinizing Hormone-Releasing Hormone Administration in Young ThalassemicPatients.- Pubertal Development in Female Thalassemics.- The Pituitary-Thyroid-Gonadal Axis in Saudi ?-Thalassaemia Patients.- Insulin-dependent Diabetes mellitus in a Group of Young People with beta-Thalassemia major.- A Transverse and Longitudinal Study of Pancreatic Function and Glucose Tolerance in Thalassemic Patients.- ?-Cell-Glucose Non-sensing in Patients with Thalassemia major and Glucose Intolerance.- Secondary Diabetes mellitus in Thalassemic Patients.- Subject-Index.
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