This book summarizes various emerging trends in endodontic disinfection. This book illustrate number of irrigating solutions and devices that are available for endodontic use, but clinician should know what suits the best for the type of case that one handles. More for judicious usage ,safety, proper precautionary measure ,rubber dam isolation, will lead to successful debridement of the canal which ensure pathogen free canal and a final overall success in the endodontic therapy.