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To enhance crop production heavy tonnage of pesticides is being used around the globe. Endosulfan, is one such organochlorine pesticide that had been is usage from a long time. It possess severe health impacts and also cause damage to the central nervous system.Antioxidants such as resveratrol on the other hand, acts to counterbalance the toxic effects of pesticides. This study was designed to evaluate the ameliorative potential of resveratrol against endosulfan induced neurotoxicity. For this different nuclei and fibre tracts of various regions of the mice brain have been mapped using histochemical localization of the neurotransmitter enzyme ATPase.