Noted experts survey and evaluate the latest research in the growing field of endothelial cell involvement in the initiation and development of various diseases. Research-oriented chapters span a diversity of topics, including endothelial cell response to various injuries and its crucial role in inflammation, immunity, viral infection, hypertension, hyperlipidemia, atherosclerosis, diabetes mellitus, neoplasia, and metastasis.
Noted experts survey and evaluate the latest research in the growing field of endothelial cell involvement in the initiation and development of various diseases. Research-oriented chapters span a diversity of topics, including endothelial cell response to various injuries and its crucial role in inflammation, immunity, viral infection, hypertension, hyperlipidemia, atherosclerosis, diabetes mellitus, neoplasia, and metastasis.
I. General.- 1. Endothelial Cell Response to Normal and Abnormal Stimuli: Modulation, Dysfunction, Injury; Adaptation, Repair, Death.- 2. Interactions of Matrix Components and Soluble Factors in Vascular Cell Responses to Injury: Modulation of Cell Phenotype.- 3. Endothelial Cell Regrowth.- 4. Modulation of Fibronectin and Thrombospondin Synthesis and mRNA Levels by Heparin in Human Endothelial and Smooth Muscle Cell Cultures.- 5. Dysfunction of the Release of Endothelium-Derived Relaxing Factor.- 6. Modulation of Endothelial Paracellular Permeability: A Mechanistic Approach.- II. Endothelial Cell in Inflammation and Immunity.- 7. Endothelial-Leukocyte Adhesion Molecules in Acute Inflammation and Atherogenesis.- 8. Leukocyte-Mediated Endothelial Injury.- 9. Endothelial Cell Adhesive Interactions: Mechanisms and Consequences.- 10. Modulation of Endothelial Cell Proliferation by Monocyte-Derived Cytokines.- 11. Recent Insights into the Mechanisms of Vascular Injury: Implications for the Pathogenesis of Vasculitis.- 12. The Role of Endothelium in the Pathophysiology of Rheumatoid Inflammation.- 13. Mechanisms of Neutrophil Migration across Endothelium.- 14. Endothelial Permeability in Inflammation: The Role of Capillaries versus Venules.- III. Endothelial Cell in Viral Infections.- 15. Response of Human Vascular Cells to Viral Infection.- IV. Endothelial Cell in Hypertension, Hyperlipidemia, and Atherosclerosis.- 16. Changes of Arterial Endothelial Cells in Chronic Hypertension with Special Reference to Regressive Changes and Replication.- 17. Specific Platelet Mediators and the Abrupt Progression of Coronary Artery Stenoses: Experimental Evidence and Potential Clinical Implications.- 18. Endothelial Dysfunction and Atherosclerosis.- 19. Artery Wall Interactions in Early Atherogenesis.- 20. Endothelial Cell Dysfunction and Injury in Experimental Hyperlipidemic Atherogenesis.- V. Endothelial Cell in Diabetes.- 21. Brain Capillary Endothelial Transport of Insulin.- 22. Vascular Endothelium and Diabetes Mellitus.- 23. Cellular and Molecular Mechanism of Glucose-Induced Diabetic Microangiopathy.- VI. Endothelial Cell in Neoplasia and Metastasis.- 24. Role of the Vascular Endothelium in Cancer Metastasis.- 25. Endothelial Cell Heterogeneity: Its Role as a Determinant of Selective Metastasis.- 26. Organotypic Endothelial Cell Surface Molecules Mediate Organ Preference of Metastasis.- 27. The Microvascular Phases of Metastasis.- 28. Possible Relationship between Vascular Permeability Factors, Endothelial Cells, and Peritumoral Brain Edema: A Neurosurgeon's Perspective.- VII. Endothelial Cell in Other Disturbances.- 29. Effects of Polyunsaturated Fatty Acids in Endothelium.- 30. Modulation of Endothelial Coagulant Properties and Barrier Function by Factors in the Vascular Microenvironment.- 31. Parathyroid Endothelium: A New Look at the Pathophysiology of Idiopathic Hypoparathyroidism.
I. General.- 1. Endothelial Cell Response to Normal and Abnormal Stimuli: Modulation, Dysfunction, Injury; Adaptation, Repair, Death.- 2. Interactions of Matrix Components and Soluble Factors in Vascular Cell Responses to Injury: Modulation of Cell Phenotype.- 3. Endothelial Cell Regrowth.- 4. Modulation of Fibronectin and Thrombospondin Synthesis and mRNA Levels by Heparin in Human Endothelial and Smooth Muscle Cell Cultures.- 5. Dysfunction of the Release of Endothelium-Derived Relaxing Factor.- 6. Modulation of Endothelial Paracellular Permeability: A Mechanistic Approach.- II. Endothelial Cell in Inflammation and Immunity.- 7. Endothelial-Leukocyte Adhesion Molecules in Acute Inflammation and Atherogenesis.- 8. Leukocyte-Mediated Endothelial Injury.- 9. Endothelial Cell Adhesive Interactions: Mechanisms and Consequences.- 10. Modulation of Endothelial Cell Proliferation by Monocyte-Derived Cytokines.- 11. Recent Insights into the Mechanisms of Vascular Injury: Implications for the Pathogenesis of Vasculitis.- 12. The Role of Endothelium in the Pathophysiology of Rheumatoid Inflammation.- 13. Mechanisms of Neutrophil Migration across Endothelium.- 14. Endothelial Permeability in Inflammation: The Role of Capillaries versus Venules.- III. Endothelial Cell in Viral Infections.- 15. Response of Human Vascular Cells to Viral Infection.- IV. Endothelial Cell in Hypertension, Hyperlipidemia, and Atherosclerosis.- 16. Changes of Arterial Endothelial Cells in Chronic Hypertension with Special Reference to Regressive Changes and Replication.- 17. Specific Platelet Mediators and the Abrupt Progression of Coronary Artery Stenoses: Experimental Evidence and Potential Clinical Implications.- 18. Endothelial Dysfunction and Atherosclerosis.- 19. Artery Wall Interactions in Early Atherogenesis.- 20. Endothelial Cell Dysfunction and Injury in Experimental Hyperlipidemic Atherogenesis.- V. Endothelial Cell in Diabetes.- 21. Brain Capillary Endothelial Transport of Insulin.- 22. Vascular Endothelium and Diabetes Mellitus.- 23. Cellular and Molecular Mechanism of Glucose-Induced Diabetic Microangiopathy.- VI. Endothelial Cell in Neoplasia and Metastasis.- 24. Role of the Vascular Endothelium in Cancer Metastasis.- 25. Endothelial Cell Heterogeneity: Its Role as a Determinant of Selective Metastasis.- 26. Organotypic Endothelial Cell Surface Molecules Mediate Organ Preference of Metastasis.- 27. The Microvascular Phases of Metastasis.- 28. Possible Relationship between Vascular Permeability Factors, Endothelial Cells, and Peritumoral Brain Edema: A Neurosurgeon's Perspective.- VII. Endothelial Cell in Other Disturbances.- 29. Effects of Polyunsaturated Fatty Acids in Endothelium.- 30. Modulation of Endothelial Coagulant Properties and Barrier Function by Factors in the Vascular Microenvironment.- 31. Parathyroid Endothelium: A New Look at the Pathophysiology of Idiopathic Hypoparathyroidism.
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