Endothelin-1 in Endotoxin and Sepsis-Induced Lung Injury - Kuklin, Vladimir
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Acute lung injury (ALI) is a common complication of different conditions like sepsis, shock and trauma, which may emerge into full-blown acute respiratory distress syndrome (ARDS). During the last 15 years, participation of the endothelin-1 (ET-1) system in the pathogenesis of ALI/ARDS has been intensively studied. In sepsis-induced acute lung injury (ALI), endothelin-1 (ET-1) is suspected of increasing lung capillary pressure and probably permeability. In present study, we studied pulmonary hemodynamic, volumetric and permeability effects of the non-selective ET-1 receptor antagonist,…mehr

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Produktbeschreibung
Acute lung injury (ALI) is a common complication of different conditions like sepsis, shock and trauma, which may emerge into full-blown acute respiratory distress syndrome (ARDS). During the last 15 years, participation of the endothelin-1 (ET-1) system in the pathogenesis of ALI/ARDS has been intensively studied. In sepsis-induced acute lung injury (ALI), endothelin-1 (ET-1) is suspected of increasing lung capillary pressure and probably permeability. In present study, we studied pulmonary hemodynamic, volumetric and permeability effects of the non-selective ET-1 receptor antagonist, tezosentan, in animals with endotoxin or sepsis-induced ALI. We also studied the activation of protein kinase C alpha and expression of mRNA for prepro-ET-1 and its receptors in animals lung tissue cells. Additionally, we investigated the relationship between the plasma concentration of ET-1 and extravascular lung water index (EVLWI) in septicemic patients.
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Autorenporträt
Education: Northern State Medical University, Arkhangelsk, Russia, 1986-1993; Appointments: Doctor-Anesthetist: City Hospital N1, Seamen's Hospitals, Arkhangelsk, 1993-2001; PhD student, University of Tromsø, Norway, 2001-2005; Doctor-anesthetist: University hospital, Tromsø, 2005-2012, hospital in Kongsberg, Norway, at present time.