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Obesity is a global epidemic that affects individuals of all ages, races, and socioeconomic statuses. It is defined as having a BMI of 30 or higher. Over the past 20 years, the prevalence of obesity has increased dramatically worldwide.Obesity is characterized by a disrupted regulation of energy balance, which leads to excessive body fat accumu-lation. It has a devastating effect on human health as it increases the risk of chronic conditions such as type 2 diabetes mellitus, hypertension, kidney diseases, heart disease, stroke, and some types of cancer. These conditions not only deteriorate the quality of life but also create a huge economic and clinical burden.The modern sedentary lifestyle and overeating are hy-pothesized to be major causes of obesity and its associated co-morbidities. However, the genetic factors also play a key role in the imbalanced energy metabolism in obesity .Obesity has been associated with genes involved in energy metabolism, which regulate energy balance, appetite, and fat storage.Therefore, understanding the genetic factors that influence energy metabolism may help in the prevention of obesity by providing effective control mechanisms.