The notion of spatial-energy parameter (P-parameter) is introduced based on the modified Lagrangian equation for relative motion of two interacting material points, which is a complex characteristic of important atomic values. Its wave properties are found, numerous calculations of equilibrium-exchange structural interactions (for nanosystems as well) are done. The concept of the entropy of spatial-energy interactions is used similarly to the ideas of thermodynamics on static entropy. The nomogram to assess the entropy of different processes is obtained. The rationality of applying such methodology when investigating the conformation of polypeptide chains and fragments of DNA molecules is demonstrated. The methodology application to the intensity assessment of fundamental interactions is given. It is demonstrated that corpuscular interactions take place along the potential gradient (principle of adding reciprocals of energies), and wave processes proceed against the potential gradient (principle of algebraic addition of energies). The equations of dependence of rotational and orbital motions of planets are given, their rotation angles are calculated.