Amit Chaudhary, Upendra Nagaich, D. K. Agrawal

Enhancement of solubilization & bioavailability of poorly soluble drug

Enhancement of aqueous solubility

• Broschiertes Buch

Produktbeschreibung

The aim of this work is to improve the solubilization and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The solubility of a solute is the maximum quantity of solute that can dissolve in a certain quantity of solvent or quantity of solution at a specified temperature. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for certain drugs. This is true for parenterally, topically and orally administered solutions. Physical modifications techniques like media milling/ nanocrystal technology, cryogenic technology, supercritical fluid process, modification of the crystal habit, complexation, micellar technologies, chemical modifications etc.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 52
• Englisch
• Abmessung: 220mm x 150mm x 3mm
• Gewicht: 86g
• ISBN-13: 9783659211577
• ISBN-10: 3659211575
• Artikelnr.: 36374527

Autorenporträt

Mr. Amit Chaudhary is currently working as Asst. Prof. of Pharmaceutics in BIT-School of Pharmacy, Meerut (U.P.) India. He is the core member of Health Quest Foundation, Chandigarh. He is serving as Secretary of NES Educational society, Meerut (U.P.). He is associated with Indian Pharmaceutical Association (IPA).