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The X-ray medical imaging is one of the dependent techniques which used in the diagnosis of the patient without resorting to surgical intervention. It considers as the relatively low cost of examination and availability in the public and private sectors. X-ray is also characterized by its ability to provide good anatomical information about bones and interference among bones and soft tissues, but is relatively unable to provide complete anatomical information about the soft tissues which located in the same site or to show the boundaries between these tissues or to distinguish between normal and abnormal soft tissues Which has a negative effect on the diagnostic ability of X-ray medical imaging. To overcome these obstacles, the contrast agents (iodine-based) were used with X-ray medical imaging for the 50 years ago, the use of these chemical components has side effects such as( kidney failure, heart stroke, negative effects on the liver and spleen) and use restrictions such as lack of Imaging time and poor contrast for obese patients. Gold nanoparticles overcome most of these restrictions with low toxicity due to its size and properties and allow for a long time of imaging.