This book introduces the study of the impacts on organizational culture, strategy, technology, human resource development (HRD), transformational leadership, knowledge management, and organizational effectiveness using a hypothesis-driven model. The model posits that organizational culture, technology, strategy, and HRD are essential preconditions for effective knowledge management, which is further enhanced by transformational leadership. Focusing on Research and Development (R&D) organizations, specifically the research institutes of the Mongolian Academy of Sciences, the study examines how these factors collectively improve organizational effectiveness. Concluding with practical recommendations for R&D specialists and managers, the book offers insights into enhancing organizational efficiency through strategic leadership and robust knowledge management practices.