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This issue of Critical Care Clinics edited by Dr. Robert Hyzy on Enhancing the Quality of Care in the ICU features topics such as: Taking Central Line-Associated Bloodstream Infection Rates to Zero, Preventing ICU Delirium, Avoiding Clostridium difficile associated diarrhea, Reducing ventilator associated complications and pneumonia, Can Venous Thromboembolism be avoided?, Preventing urinary catheter associated infections, Improving ICU quality through collaboratives, Do performance measures enhance patient quality in the ICU, and The Future of Quality in the ICU.