The book shows the results of the Global University Entrepreneurial Spirit Students' Survey (GUESSS) research project conducted at the Universidad de La Frontera, Temuco, Chile from March to June 2021. The objective of GUESSS is to analyze the entrepreneurial intention and activity of university students through the application of an online survey conducted every two years. In each cycle of data collection, GUESSS has been consolidating and is implemented in more and more countries, culminating in its ninth version in 2021, with more than 58 participating countries and more than 267,000 students responding to the completed questionnaire. The latter makes GUESSS one of the largest studies on university entrepreneurship in the world. The analysis of the information collected is what will serve as input to present the main results obtained for the Universidad de La Frontera in relation to the entrepreneurial intention and activity of its students, which will help the university to evaluate the effectiveness and quality of its programs in the context of entrepreneurship.