Despite the availability of hydroxypropyl starch (HPS) as commercial water soluble starch derivatives, synthesis of HPS through hydroxypropylation of maize starch was systematically studied in current work. This was done with a view to have tailored HPS products which can better serve as a reducing and stabilizing agent during the preparation of silver nanoparticles. Solution containing 1620 ppm silver nanoparticles was diluted to 50 ppm and 100 ppm The diluted solutions were applied to cotton fabrics in presence and absence of a binder to impart antibacterial properties to the fabrics. Solution containing 50 ppm silver nanoparticles induce excellent and durable bactericidal activity to cotton fabrics.