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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The Enzyme Function Initiative (EFI) is a large scale collaborative project aiming to develop and disseminate a robust strategy to determine enzyme function through an integrated sequence-structure based approach. The project was funded in May 2010 by the National Institute of General Medical Sciences as a Glue Grant which supports the research of complex biological problems that cannot be solved by a single research group. The EFI was largely spurred by the need to develop methods to identify the functions of the enormous number proteins discovered through genomic sequencing project