Enzyme Mimic to Develop Antioxidant Nanoreactors - Balasubramanian, Vimalkumar
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Reactive oxygen species have been implicated in various diseases, but attempts to find efficient antioxidant treatments for such conditions have met with only limited success. This work describes an antioxidant nanoreactor obtained by encapsulating a dual-enzyme mimic in polymeric nanovesicles. As the mimic detoxifies in situ both superoxide radicals and related hydrogen peroxide, the nanoreactor exhibits antioxidant activity in THP-1 cells. Development of this simple, robust antioxidant nanoreactor represents a new direction in efficiently fighting oxidative stress.

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Produktbeschreibung
Reactive oxygen species have been implicated in various diseases, but attempts to find efficient antioxidant treatments for such conditions have met with only limited success. This work describes an antioxidant nanoreactor obtained by encapsulating a dual-enzyme mimic in polymeric nanovesicles. As the mimic detoxifies in situ both superoxide radicals and related hydrogen peroxide, the nanoreactor exhibits antioxidant activity in THP-1 cells. Development of this simple, robust antioxidant nanoreactor represents a new direction in efficiently fighting oxidative stress.
Autorenporträt
Dr. Vimalkumar Balasubramanian graduated in Microbiology as well as in Nanotechnology and received his PhD degree in Chemistry. His research interests are focused on pharmaceutical nanotechnology for the development of nano-carrier systems.