Eosinophil mediators & their toxicity on Breast Cancer cells - Law, Michelle
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Eosinophils are known for their role as anti-helminthic agents & as inflammatory effectors in allergic hypersensitivity &bronchial asthma. Their granules contain extremely cytotoxic proteins which are responsible for damage to the normal epithelia, & contribute to allergic responses & the onset of asthma. Preliminary observations had shown tumor cell growth was inhibited by a crude eosinophil protein extract & partially inhibited by IL-4 & TNF- ; also produced by eosinophils. Characterization of the protein isolated from the granules confirmed its identity as that of the eosinophil major basic…mehr

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Produktbeschreibung
Eosinophils are known for their role as anti-helminthic agents & as inflammatory effectors in allergic hypersensitivity &bronchial asthma. Their granules contain extremely cytotoxic proteins which are responsible for damage to the normal epithelia, & contribute to allergic responses & the onset of asthma. Preliminary observations had shown tumor cell growth was inhibited by a crude eosinophil protein extract & partially inhibited by IL-4 & TNF- ; also produced by eosinophils. Characterization of the protein isolated from the granules confirmed its identity as that of the eosinophil major basic protein as demonstrated by silver stain & western blot. The growth of both cancer cell lines was significantly inhibited by the protein isolate alone & in combination with select inflammatory & non-inflammatory cytokines. Additional results showed that the combination of protein isolate and selected cytokines differentially down-regulated the expression of oncogenes in the cell lines. The results demonstrate the functional potency of this eosinophil granular mediator in inhibiting in vitro tumor cell growth & suggest an effector role for this cell in the host response against breast cancer.
Autorenporträt
Dr. Law earned her PhD from Howard University in Washington, DC & completed her post doc at theUniv. of Michigan, Ann Arbor in the Department of Pathology. Upon finishing her training, she hasfocused her career on ensuring the quality of medical products (drugs, biologics and devices) with a particular focus on microbiological safety.