The nosocomial infection represents a public health problem, the surveillance of the IN has become a necessity. The objective is to determine the profile and risk factors of nosocomial infections.This is a retrospective descriptive and analytical study conducted in the intensive care unit, CHU of Setif(January 1 to December 31, 2017). The data were collected from medical records. Data entry and analysis (Epi Info version 3.5.3 and Excel 2007). The population (108 patients), sex ratio (1.51), prevalence rate IN: 21.30% (23 patients), with a female predominance.49 nosocomial infections were notified or an average of 2 infections per infected patient. Urinary tract infections +++ (30.40%), ENT infections (17.40%), septicemia and catheter infections (15.2%), Acinetobacter baumanii and Candida albicans ++ (20.75%). More than 50% of germs are resistant to amoxicillin. Acinetobacter baumanii is the most resistant germ to (75%). Longer stay, hot season, corticosteroids and some invasive devices are the main risk factors in our study.
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