Epilepsy is the world's most common serious disorder of the brain according to World Health Organization. Epilepsy is a chronic disorder in which the recurrence of seizures is the indispensable feature that is typically unprovoked and usually unpredictable. An epileptic seizure is the outcome of a temporary physiologic dysfunction of the brain caused by a self-limited, abnormal, hypersynchronous electrical discharge of cortical neurons. A seizure is a transient epileptic event, a symptom of disturbed brain function. Unfortunately presently available antiepileptic drugs are synthetic compounds and have limited efficacy and their major side effects limit their use and cause difficulties in patient management. The Unani system of medicine which plays an important role in treating various nervous disorders, offers a number of drugs useful in the management of convulsive disorders. Majoon Najah is an age old, time tested polyherbal preparation of Unani system of medicine which is commonly used for the treatment of epilepsy (Sar') and other neurological disorders.