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Substantial international support has been provided to Africa to help the continent harness science, technology, and innovation opportunities to address its critical food insecurity and malnutrition challenges. However, African countries remain among the most affected by these challenges. Agricultural biotech, although largely utilized in America and Asia with compelling results, is still disregarded by most African countries.This book explores the importance of ethics and SEC in the biotechnology debate in Africa, and the role of the new construct of biosafety communication in addressing these non-safety aspects of the technology. The research investigates the role of the biosafety communication approach in relation to the often-ignored facets of ethics and SEC in biotech. The investigation harnesses a triangulated research approach that reviews the existing academic and scientific literature and content analysis of existing data, as well as semi-structured interviews with key stakeholders in four African countries within three regional economic communities.