Is it possible to compare the effectiveness of a course delivered online at a distance with a traditional face-to-face course? Many studies have tried and failed to find any significant difference between on-line and face-to-face courses due to poor research design and rigor. What is needed is a research model for conducting online and classroom comparison studies to provide consistency in research design, analysis, and reporting. This book provides a research model that includes the basics of describing the delivery (mediated) framework, appropriate research design and data analysis selection, and a blueprint for conducting and reporting the cost-benefit ratio based on a cost-benefit analysis. To provide an example of the model in action it was applied to First Connections, an online infant and toddler care provider-training program. This research model will be useful to education researchers and others in the education and educational technology fields.