Evaluation anti-Trypanosoma cruzi of aminoguanidine derivatives - Pinheiro II, Miguel
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Chagas disease, a widely distributed parasitic infection in Latin America, is a serious public health problem with devastating consequences in terms of human morbidity and mortality. Existing therapeutic alternatives are limited and insufficient mainly due to low efficacy and high toxicity. Aiming at the planning of new antichagasic agents, we developed in this work the synthesis of five new substances, containing the indol and aminoguanidine hydrazones with potential anti-T. cruzi activity and their biological evaluation.

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Produktbeschreibung
Chagas disease, a widely distributed parasitic infection in Latin America, is a serious public health problem with devastating consequences in terms of human morbidity and mortality. Existing therapeutic alternatives are limited and insufficient mainly due to low efficacy and high toxicity. Aiming at the planning of new antichagasic agents, we developed in this work the synthesis of five new substances, containing the indol and aminoguanidine hydrazones with potential anti-T. cruzi activity and their biological evaluation.
Autorenporträt
Licenciado en Farmacia (CESMAC) 2003, Especialista en Manipulación Farmacéutica (CESMAC-UFRRJ), 2005, MBA en Gestión Industrial Farmacéutica (IPOG), 2014, Master en Ciencias Farmacéuticas (UFAL) 2016, Doctor en Ciencias Farmacéuticas (UFPE), 2016.