Evaluation of Genotype MTBDRplus Assay for MDRTB Diagnosis in Nepal - Dahal, Bimal
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Multidrug-resistant (MDR) strains are serious threats to the control of tuberculosis and comprise an increasing public health problem. The worldwide increase in multidrug-resistant (MDR) tuberculosis has made the timely identification of resistant M. tuberculosis complex (MTBC) strains extremely important to achieve effective disease management. This study was performed with an objective to compare culture based proportion method with Genotype MTBDRplus reverse hybridization probe assay for identifying MDR-TB strains from suspected multi drug resistant cases, referred to GENETUP Kathmandu,…mehr

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Produktbeschreibung
Multidrug-resistant (MDR) strains are serious threats to the control of tuberculosis and comprise an increasing public health problem. The worldwide increase in multidrug-resistant (MDR) tuberculosis has made the timely identification of resistant M. tuberculosis complex (MTBC) strains extremely important to achieve effective disease management. This study was performed with an objective to compare culture based proportion method with Genotype MTBDRplus reverse hybridization probe assay for identifying MDR-TB strains from suspected multi drug resistant cases, referred to GENETUP Kathmandu, Nepal. A commercially available new Genotype MTBDRplus assay (Hain Lifescince, GmBH, Nehern, Germany) was evaluated for its ability to detect mutations in Mycobacterial isolates conferring resistance to rifampin (RMP) and isoniazid (INH). MTBDRplus assay was designed to detect the mutations in the regulatory region of inhA.
Autorenporträt
Mr. Bimal Dahal has obtained his Master Degree in Medical Microbiology from Kathmandu College fo Science and Technology(Tribhuvan University) in 2010. Since then he has involved in different research projects like Tuberculosis,Intestinal parasites. He is also involved in Teaching Activities in Government Funded Institution as a Biology Teacher.