Jéssica Cristiane Oliveira Costa

Evaluation of gingival collagen in rats immunosuppressed with CsA

Evaluation of gingival collagen in experimental periodontitis in rats immunosuppressed with CsA

• Broschiertes Buch

Produktbeschreibung

Cyclosporine A (CsA) is an immunosuppressant drug used mainly in transplant patients and can have the adverse effect of causing gingival hyperplasia. Some studies have shown that this increase may be due to a change in fibroblast metabolism and connective tissue homeostasis, characterizing this condition as a risk for periodontal disease. The aim of this study was to compare gingival connective tissue in experimental periodontitis in rats immunosuppressed with CsA. Twenty-eight male rats (Wistar) were used, 14 treated with daily doses of 10mg/kg of CsA and 14 treated with NaCl. After 60 days, a ligature was inserted around the 2nd upper right molar, maintained for 7 days and then 14 days to induce experimental periodontitis (T), with the contralateral molar as a control (C). After sacrificing the animals, the jaws were processed for histological analysis and 5 semi-serial sections per specimen were stained with picrosirious to quantify the collagen.

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Produktdetails

• Verlag: Our Knowledge Publishing
• Seitenzahl: 52
• Erscheinungstermin: 30. Mai 2024
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 96g
• ISBN-13: 9786207606856
• ISBN-10: 620760685X
• Artikelnr.: 70834445

Autorenporträt

Abschluss in Zahnmedizin an der Universität von Taubaté - UNITAU im Jahr 2013 Spezialisierung: Kieferorthopädie Autor des Artikels: Bewertung des gingivalen Kollagens bei experimenteller Parodontitis bei Ratten, die mit CsA immunsupprimiert wurden