Vichitra Kaushik, Ratan Lal Khosa, Versha Parcha

Evaluation of New Bicyclic Lactone 'Michelianone'

as Anti-Inflammatory Principle from Michelia Oblonga Leaf Extract

• Broschiertes Buch

Produktbeschreibung

A novel bicyclic lactone 'Michelianone' (P4) has been isolated from anti-inflammatory activity guided fractionation of chloroform extract of Michelia oblonga leaf with a gradient of ethyl acetate in petroleum ether. Further P4 was screened for anti- inflammatory activity on carrageenan and dextran induced inflammation model in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P4 has showed significant reduction in inflammation caused by carrageenan (P<0.01) and dextran (P<0.05). Hence P4 can be considered as the principle component responsible for the anti- inflammatory activity for Michelia oblonga leaf. The characterization of P4 was done by spectral studies like IR, 1H-NMR, 13C-NMR & Mass Spectroscopy. On the basis of spectral studies the structure of P4 has been elucidated as bicyclic lactone. This is a novel bicyclic lactone isolated from the leaf of M. oblonga for the first time and given a trivial name Michelianone.

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Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 84
• Erscheinungstermin: 7. Februar 2011
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 143g
• ISBN-13: 9783843353090
• ISBN-10: 3843353093
• Artikelnr.: 32980995

Autorenporträt

Dr. Vichitra Kaushik currently working as Associate Prof in M.M.College of Pharmacy, Maharishi Markandeshwar Univ., Mullana, Ambala, Haryana, India, Dr. R L Khosa, formerly Prof and HOD Pharmacy, IT, BHU, India, Currently Director (P&D) Pharmacy, BIT, Meerut, India and Dr. Versha Parcha as Prof inDOPS, S.B.S.P.G.I., Dehradun, UK, India.