Vichitra Kaushik, Versha Parcha, Ratan Lal Khosa

Evaluation of New Lupane-Type Triterpene 'Diospyrosonate'

as Anti-Inflammatory Principle from Diospyros malabarica Bark Extract

• Broschiertes Buch

Produktbeschreibung

A novel lupane-type triterpene 'Diospyrosonate' (P1) has been isolated from anti-inflammatory activity guided fractionation of petroleum ether extract precipitate of Diospyros malabarica stem bark with a gradient of ethyl acetate in petroleum ether. Further P1 was screened for anti- inflammatory activity on carrageenan and dextran induced inflammation model in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P1 has showed significant reduction in inflammation caused by carrageenan (P<0.05) and dextran (P<0.01). Hence P1 can be considered as the principle component responsible for the anti-inflammatory activity for Diospyros malabarica bark.The characterization of P1 was done by spectral studies like IR, 1H-NMR, 13C-NMR & mass spectroscopy. On the basis of spectral studies the structure of P1 has been elucidated as Betulin esterified at C-29 with a C-14 acid. This is a novel triterpenoid isolated from the bark of D. malabarica for the first time andgiven a trival name Diospyrosonate.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 84
• Erscheinungstermin: 26. Januar 2011
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 143g
• ISBN-13: 9783844301045
• ISBN-10: 3844301046
• Artikelnr.: 32771029

Autorenporträt

Dr. Vichitra Kaushik currently working as Associate Prof in M.M.College of Pharmacy, Maharishi Markandeshwar Univ., Mullana, Ambala, Haryana, India, Dr. R L Khosa, formerly Prof and HOD Pharmacy, IT, BHU, India, Currently Director (P&D) Pharmacy, BIT, Meerut, India and Dr. Versha Parcha as Prof inDOPS, S.B.S.P.G.I., Dehradun, UK, India.