The Government of Rwanda considers the private sector to play an important role in supporting provision of strategic national investments through Public-Private Partnerships (PPPs). This study aims to describe the various aspects of PPPs in Health Supply Chain Management (HSCM) in Rwanda. The PPP interventional areas used in HSCM in Rwanda were namely supply of commodities (99%), delivered health Information Technology (IT) supplies and equipment (operate) (53%), finance (52%), and maintenance area (40%). The main challenges were limited conversation and absence of formal platforms for public and private engagement (83.7%) and complex procurement requirements for medical products and equipment by public institutions (73.3%). The strategies to improve the PPPs in HSCM were effective coordination of PPPs (93.3%) and improved dialogue and formal platforms (90.6%). These findings indicated that private sector through PPPs plays an important role in HSCM in Rwanda. The engagement of the private sector can increase the financial support in terms of financing HSCM activities like supply of health commodities and equipment.