The liver plays very crucial role in the body such as detoxification of dangerous substances among other numerous functions. Injury to the liver compromises such vital functions with fatal consequences. Acetaminophen is an over-the -counter analgesic drug that is abused on daily basis with attendant consequences of precipitating various hepatic disorders. Quail egg on the other hand is recently gaining popularity regarding its various therapeutic potentials. There are a lot of documented testimonies of the healing properties of quail egg. This study therefore was designed to evaluate the possible ameliorative effects of pre-treatment with quail egg solution on acetaminophen-induced hepatotoxicity in rats. Quail egg solution of varying concentrations were administered over a period before inducing hepatic injury with overdose of acetaminophen in rats. Thereafter, some parameters that usually indicate tissue injuries were investigated. The findings are interesting!