Pneumonia is a real public health problem in the world and particularly in developing countries where it is ranked among the first causes of infant mortality. The limitations of antibiotic therapy, reflected in the emergence of resistant strains, have inspired the search for new therapeutic strategies. This work is therefore in line with this framework with the objective of evaluating the antibacterial activity of extracts of endophytic fungi isolated from the bark and leaves of Alstonia boonei and the bark of Greenwayodendron suaveolens on the growth of four bacteria responsible for pneumonia. For this purpose, A. boonei and G. suaveolens were respectively collected in Ngoa-ékellé and Nkolbisson, neighborhoods located in Yaoundé in the Central Cameroon Region. They then undergo a series of surface disinfections and are cut, dried and isolated in PDA medium and incubated until pure cultures are obtained. These cultures are again subcultured in PDA medium and then in SDA and CDA medium for grouping on the basis of macroscopic and microscopic characteristics. The screening of these fungi