The general objective of this work is to evaluate the efficiency of the wastewater management system of the Yaoundé University Hospital Center (C.H.U).Tests were conducted from December 2012 to March 2013 at the scale of a pilot plant built at the former wastewater treatment plant of the University of Yaoundé I CHU now abandoned in order to study the treatment efficiency of two natural wastewater treatment systems in series consisting of a planted filter and lagoon. Two hydraulic loads, respectively 3 l/d and 5 l/d were tested with one repetition each. While for the lagoon system, two retention times were studied. The wastewater was collected from the different compartments of the system, kept in a refrigerated cooler and brought back to the laboratory for monitoring of physicochemical and bacteriological parameters following standard protocols.