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The edible crustaceans, Erugosquilla massavensis, Penaeus semisulcatus , Metapenaeus monoceros (shrimps) and Portunus pelagicus (crab), from different regions are important components of the aquatic fauna . These edible crustaceans can be beneficial as nutraceutical and pharmaceutical components, if we can use in the treatment of some diseases. So, the purpose of the present work was, therefore, to assess the protein, carbohydrates, and lipids, vitamins (B1, B2), minerals (K, Na, Ca, P, S) of these species, which may in the future play an important role in some pharmaceutical industries and may be used as specific health foods (functional supplements).Other species, crawfish Procambarus clarkii now represent a problem to the Egyptian fishermen, farmers and for the river Nile environment.Also, The present work showed that, it could be biologically managed through introducing it as cheap food that can contribute to aquatic animal proteins. Moreover, comparative studies were carriedout with two high priced marine shrimps namely : Penaeus japonicus and Penaeus semisulcatus. The former was obtained from lake Quarun while the latter from the Suez Gulf.