Evaluation of Triterpenoidal Anti-Inflammatory Principle - Kaushik, Vichitra;Parcha, Versha;Khosa, Ratan Lal
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A triterpenoidal compound (P2) has been isolated from anti-inflammatory activity guided fractionation of acetone extract of Drypetes roxburghii leaf with a gradient of methanol in chlroform. Further P2 was screened for anti-inflammatory activity on carageenan and dextran induced inflammation models in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P2 has showed significant reduction in inflammation caused by carrageenan (P0.01) and dextran (P0.05). Hence P2 can be considered as the active component responsible for the anti-inflammatory activity of Drypetes…mehr

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Produktbeschreibung
A triterpenoidal compound (P2) has been isolated from anti-inflammatory activity guided fractionation of acetone extract of Drypetes roxburghii leaf with a gradient of methanol in chlroform. Further P2 was screened for anti-inflammatory activity on carageenan and dextran induced inflammation models in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P2 has showed significant reduction in inflammation caused by carrageenan (P0.01) and dextran (P0.05). Hence P2 can be considered as the active component responsible for the anti-inflammatory activity of Drypetes roxburghii leaf. The characterization of P2 was done by spectral studies like IR, 1H-NMR, 13C-NMR & Mass Spectroscopy. On the basis of spectral studies the structure of P2 has been elucidated as triterpenoidal compound.
Autorenporträt
Dr. Vichitra Kaushik currently working as Associate Prof in M.M.College of Pharmacy, Maharishi Markandeshwar Univ., Mullana, Ambala, Haryana, India, Dr. R L Khosa, formerly Prof and HOD Pharmacy, IT, BHU, India, Currently Director (P&D) Pharmacy, BIT, Meerut, India and Dr. Versha Parcha as Prof inDOPS, S.B.S.P.G.I., Dehradun, UK, India.