The research is centering on relationship in containerization and the development of multi-modal transportation. The research examines how socioeconomic factors might have justified the concurrent modernization of two industries of containerization and multi-modal transportation. The study gives an account of how the interdependence relationship that subsists between the two industries. International trade law is also used in explaining the problems and the opportunities that might be associated with that interdependence relationship. Most case studies used in this work are based on developments within the shipping industry among companies in the European Union (E.U) and some parts of Asia. The research examines lessons that can be learnt from the relationship in development of containerization in the multi-modal transportation. The above interrelationship cuts across global nature of the developments in the industries while increasing the complexities associated with the allocation liability for loss and risks under international trade. The work also credits the role of interdependence relationships in responding to some of challenges around the transportation industry.