Ex Vivo Engineering of the Tumor Microenvironment

Herausgegeben:Aref, Amir R.; Barbie, David

• Broschiertes Buch

Produktbeschreibung

This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo . Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.

Produktdetails

• Cancer Drug Discovery and Development
• Verlag: Humana / Springer International Publishing / Springer, Berlin
• Artikelnr. des Verlages: 978-3-319-83282-1
• Softcover reprint of the original 1st ed. 2017
• Seitenzahl: 135
• Englisch
• Abmessung: 8mm x 155mm x 235mm
• Gewicht: 237g
• ISBN-13: 9783319832821
• ISBN-10: 3319832824
• Artikelnr.: 53582550

Autorenporträt

Amir R. Aref, PhD, is Instructor, Dana-Farber Cancer Institute, Harvard Medical School.

Inhaltsangabe

1.Introduction to Ex Vivo Cancer Models.- 2.Patient-derived Xenografts in Oncology.- 3.Organoid Culture: Applications in Development and Cancer.- 4.Microfluidics and future of cancer diagnostics.- 5.Advancing techniques and insights in circulating tumor cell (CTC) research.- 6.The Cancer Secretome.- 7.An overview of the tumor microenvironments and future of cancer therapy.