Faced with the social, moral and political deterioration of the present, there is a call to think about reforms to our ways of being and living together in the world. In this article we propose the transition from a biological immunology to a general immunology stimulated by different social agents and present a methodology towards a citizenship understood as immunological, general and social. We stick mainly to giving a propositional horizon of the Exercise, a category in Peter Sloterdijk that we use in this work as a practical philosophy, and we inquire into the possibilities that this training has as a driving force for world change. This Psycho-Political-Aesthetics, based on the notion of citizenship, is presented and tangible in a social body, which stimulates this mass intelligence as a method and which is founded as a general immunological agent for overcoming the current conflict. In this way, we put forward various recommendations on what to exercise and what skills to cultivate in order to face the present century and its crises.