Carcinogenesis and Bioassays International Symposium Held at the Battelle Seattle Research Center Seattle, WA, USA, June 23¿26, 1974 Herausgegeben von Karbe, E.; Park, J.F.
Carcinogenesis and Bioassays International Symposium Held at the Battelle Seattle Research Center Seattle, WA, USA, June 23¿26, 1974 Herausgegeben von Karbe, E.; Park, J.F.
These are the proceedings of the international symposium on "Experi mental Respiratory Carcinogenesis and Bioassays", held from 23 to 26 June 1974 at the Battelle Seattle Research Center, Seattle, Wash., USA. Human lung cancer is already very common in industrialized countries, and its incidence is increasing. This increase involves mainly epi dermoid and small-cell carcinoma. Evidence is accumulating that these tumors are associated with such exogenic factors as automobile exhaust, asbestos, chemicals, cigarette smoke, and radionuclides. These pro ceedings are concerned with finding the most…mehr
These are the proceedings of the international symposium on "Experi mental Respiratory Carcinogenesis and Bioassays", held from 23 to 26 June 1974 at the Battelle Seattle Research Center, Seattle, Wash., USA. Human lung cancer is already very common in industrialized countries, and its incidence is increasing. This increase involves mainly epi dermoid and small-cell carcinoma. Evidence is accumulating that these tumors are associated with such exogenic factors as automobile exhaust, asbestos, chemicals, cigarette smoke, and radionuclides. These pro ceedings are concerned with finding the most suitable experimental designs for investigating the genesis of these particular types of tumor, and with the development of specific bioassays to test sus pected carcinogens. Spontaneous epidermoid and small-cell carcinomas are extremely rare in the respiratory organs of animals, and it has proved rather diffi cult until recently to produce them experimentally. Epidermoid carci nomas are nowreadily obtained by using methods of intratracheal in stillation of carcinogens with particulate materials such as that described by SAFFIOTTI and co-workers, which is the technique most frequently mentioned in these proceedings. While the experimental production of small-cell carcinomas has remained difficult, it is described by two authors in this volume.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Keynote Address: Progress in Respiratory Carcinogenesis.- Session I Methods in Experimental Respiratory Carcinogenesis and Bioassays. Chairman: S. LASKIN.- Models in Chemical Respiratory Carcinogenesis.- The Role of the Host in the Development of in vivo Models for Carcinogenesis Studies.- The Significance of Aryl Hydrocarbon Hydroxylase Enzyme Systems in the Selection of Model Systems for Respiratory Carcinogenesis.- Pulmonary Carcinogenesis by Two Aryl Hydrocarbons on Three Mouse Strains.- Cell-Mediated Immunity after Intratracheal Exposure to 3-Methylcholanthrene, and its Relationship to Tumor Transplant Growth in C3H/f Mai Mice.- The Influence of Carcinogenic Substances Introduced Intratracheally to Several Generations of Experimental Rats.- Large-Volume Intratracheal Instillation of Particulate Suspensions to Hamsters.- The Intrapleural Route as a Means for Estimating Carcinogenicity.- Localized Submucosal Bronchial Injections of Carcinogens in Dogs.- Studies of Intrabronchial Particle Deposition Using Hollow Bronchial Casts.- The Distribution and Retention of Selected Metals in Rat Tissue after Inhalation of Cadmium Oxide Aerosols.- Conception and Methods of Experimental Studies in Germany to Estimate the Carcinogenic Burden by Air Pollution in Man.- Experimental Carcinogenicity and Bioassays of Automobile Exhaust Condensate and Its Polycyclic Aromatic Hydrocarbons.- Session II Multifactorial Respiratory Carcinogenesis and Related Bioassays. Chairman: P. NETTESHEIM.- Review and Introductory Remarks: Multifactorial Respiratory Carcinogenesis.- Morphogenesis of Experimental Lung Tumors in Hamsters: The Effects of Carrier Dust.- Role of Particles in Respiratory Carcinogenesis Bioassay.- Effect of Particulate Benzo(a)pyrene Carrier on Carcinogenesis in the RespiratoryTract of Hamsters.- Chemical Induction of Lung Carcinomas in Rats.- Synergistic Effects of Benzo(a)pyrene and N-Methyl-N-Nitrosourea on Respiratory Carcinogenesis in Syrian Golden Hamsters.- The Effects of Particulates on Respiratory Carcinogenesis by Diethylnitrosamine.- Respiratory Cocarcinogenesis Studies with Ferric Oxide: A Test Case of Current Experimental Models.- Induction of Pulmonary Tumors in Mice by Oral Administration of a 5-Nitrofuran Derivative.- Surface Morphology of Tracheal Epithelium in Vitamin A Deficiency and Reversal.- Postinfluenzal Pulmonary Lesions in Vitamin A Deficient Mice.- Influenza-Virus-Induced Hyperplasia of. the Respiratory Tract of the Hamster.- Inoculation of Owl Monkeys (Aotus trivirgatus) with 7,12-Dimethylbenz(a)anthracene and Herpesvirus saimiri. Induction of Epidermoid Carcinoma in the Lung.- Session III Bioassays of Respiratory Carcinogens in Tobacco Products. Chairman: W.P. DONTENWILL.- Review and Introductory Remarks: Bioassays of Respiratory Carcinogens in Tobacco Products.- A Modified Method for Locating Labeled Smoke Particles in Organs of Syrian Golden and European Hamsters.- Dotriacontane-16,17-14C Distribution Pattern in the Respiratory System of Two Hamster Species after Passive Exposure to Radioactive Labeled Smoke.- Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters.- Tumorigenic Effect of Chronic Cigarette Smoke Inhalation on Syrian Golden Hamsters.- Effect of Chronic Exposure to Cigarette Smoke on Tumor Incidence in the Syrian Golden Hamster.- Carcinogenicity of Inhaled Cigarette Smoke in the NMU-Pretreated Hamster Larynx.- Validity of the Sebaceous Gland Test and the Hyperplasia Test for the Prediction of the Carcinogenicity of Cigarette Smoke Condensates and Their Fractions.- Squamous Carcinoma of the Lung from Cigarette Smoke Condensate in Implanted Beeswax Pellets.- Session IV Radiation Carcinogenesis and Bioassays. Chairman: J.F. PARK.- Radiation Carcinogenesis. Introductory Remarks.- The Effects of Inhaled Uranium Mine Air Contaminants in Beagle Dogs.- Lesions and Lung Cancers Induced in Rats by Inhaled Radon 222 at Various Equilibriums with Radon Daughters.- Studies of Pulmonary Carcinogenesis in Rodents Following Inhalation of Transuranic Compounds.- Lung Irradiation with Static Plutonium Microspheres.- Respiratory Carcinogenesis in Rats after Inhalation of Radioactive Aerosols of Actinides and Lanthanides in Various Physicochemical Forms.- Pulmonary Carcinogenesis and Chronic Beta Irradiation of Lung.- Histologic Observations on the Pathogenesis of Lung Cancer in Hamsters Following Administration of Polonium-210.- Cellular Localization of Intratracheally Administered 210Po in the Hamster Lung Using Autoradiography of Thin Sections from Plastic Embedded Tissue.- Experimental Respiratory Carcinogenesis: Interaction between Alpha Radiation and Benzo(a)pyrene in the Hamster.- Session V In vitro Bioassays of Respiratory Carcinogens. Chairman: M.B. SPORN.- Review and Introductory Remarks: The Role of Organ Culture and Cell Culture Methods in Studies of Respiratory Carcinogenesis and Anti-Carcinogenesis.- Interactions between Radiation and Benzo(a)pyrene in an in vitro Model for Malignant Transformation.- Dose Dependence of Carcinogen-Induced Changes in Tracheal Epithelium in Organ Culture.- Topical Application of Polycyclic Hydrocarbons to Differentiated Respiratory Epithelium in Long-Term Organ Cultures.- The Bioassay of Carcinogenesis: Effects on the Epithelial Cell Complement of Rat Tracheae Maintained in vitro.- Effects of Cigarette Smoke Condensate (CSC) on RatFetal Lung in Organ Culture.- Tracheal Grafts.- Studies of Ultrastructure, Cytochemistry, and Organ Culture of Human Bronchial Epithelium.- Studies on Carcinogen Binding in vitro in Isolated Hamster Tracheas.- The Reversal of Keratinized Squamous Metaplastic Lesions of Vitamin A Deficiency in Tracheobronchial Epithelium by Vitamin A and Vitamin A Analogs in Organ Culture: A Model System for Anti-Carcinogenesis Studies.- Transformation of Nonvirus Producing BALB/3T3 Cells by an Environmental Extract.- Concluding Remarks: Progress in Respiratory Carcinogenesis Bioassays.- List of Contributors.
Keynote Address: Progress in Respiratory Carcinogenesis.- Session I Methods in Experimental Respiratory Carcinogenesis and Bioassays. Chairman: S. LASKIN.- Models in Chemical Respiratory Carcinogenesis.- The Role of the Host in the Development of in vivo Models for Carcinogenesis Studies.- The Significance of Aryl Hydrocarbon Hydroxylase Enzyme Systems in the Selection of Model Systems for Respiratory Carcinogenesis.- Pulmonary Carcinogenesis by Two Aryl Hydrocarbons on Three Mouse Strains.- Cell-Mediated Immunity after Intratracheal Exposure to 3-Methylcholanthrene, and its Relationship to Tumor Transplant Growth in C3H/f Mai Mice.- The Influence of Carcinogenic Substances Introduced Intratracheally to Several Generations of Experimental Rats.- Large-Volume Intratracheal Instillation of Particulate Suspensions to Hamsters.- The Intrapleural Route as a Means for Estimating Carcinogenicity.- Localized Submucosal Bronchial Injections of Carcinogens in Dogs.- Studies of Intrabronchial Particle Deposition Using Hollow Bronchial Casts.- The Distribution and Retention of Selected Metals in Rat Tissue after Inhalation of Cadmium Oxide Aerosols.- Conception and Methods of Experimental Studies in Germany to Estimate the Carcinogenic Burden by Air Pollution in Man.- Experimental Carcinogenicity and Bioassays of Automobile Exhaust Condensate and Its Polycyclic Aromatic Hydrocarbons.- Session II Multifactorial Respiratory Carcinogenesis and Related Bioassays. Chairman: P. NETTESHEIM.- Review and Introductory Remarks: Multifactorial Respiratory Carcinogenesis.- Morphogenesis of Experimental Lung Tumors in Hamsters: The Effects of Carrier Dust.- Role of Particles in Respiratory Carcinogenesis Bioassay.- Effect of Particulate Benzo(a)pyrene Carrier on Carcinogenesis in the RespiratoryTract of Hamsters.- Chemical Induction of Lung Carcinomas in Rats.- Synergistic Effects of Benzo(a)pyrene and N-Methyl-N-Nitrosourea on Respiratory Carcinogenesis in Syrian Golden Hamsters.- The Effects of Particulates on Respiratory Carcinogenesis by Diethylnitrosamine.- Respiratory Cocarcinogenesis Studies with Ferric Oxide: A Test Case of Current Experimental Models.- Induction of Pulmonary Tumors in Mice by Oral Administration of a 5-Nitrofuran Derivative.- Surface Morphology of Tracheal Epithelium in Vitamin A Deficiency and Reversal.- Postinfluenzal Pulmonary Lesions in Vitamin A Deficient Mice.- Influenza-Virus-Induced Hyperplasia of. the Respiratory Tract of the Hamster.- Inoculation of Owl Monkeys (Aotus trivirgatus) with 7,12-Dimethylbenz(a)anthracene and Herpesvirus saimiri. Induction of Epidermoid Carcinoma in the Lung.- Session III Bioassays of Respiratory Carcinogens in Tobacco Products. Chairman: W.P. DONTENWILL.- Review and Introductory Remarks: Bioassays of Respiratory Carcinogens in Tobacco Products.- A Modified Method for Locating Labeled Smoke Particles in Organs of Syrian Golden and European Hamsters.- Dotriacontane-16,17-14C Distribution Pattern in the Respiratory System of Two Hamster Species after Passive Exposure to Radioactive Labeled Smoke.- Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters.- Tumorigenic Effect of Chronic Cigarette Smoke Inhalation on Syrian Golden Hamsters.- Effect of Chronic Exposure to Cigarette Smoke on Tumor Incidence in the Syrian Golden Hamster.- Carcinogenicity of Inhaled Cigarette Smoke in the NMU-Pretreated Hamster Larynx.- Validity of the Sebaceous Gland Test and the Hyperplasia Test for the Prediction of the Carcinogenicity of Cigarette Smoke Condensates and Their Fractions.- Squamous Carcinoma of the Lung from Cigarette Smoke Condensate in Implanted Beeswax Pellets.- Session IV Radiation Carcinogenesis and Bioassays. Chairman: J.F. PARK.- Radiation Carcinogenesis. Introductory Remarks.- The Effects of Inhaled Uranium Mine Air Contaminants in Beagle Dogs.- Lesions and Lung Cancers Induced in Rats by Inhaled Radon 222 at Various Equilibriums with Radon Daughters.- Studies of Pulmonary Carcinogenesis in Rodents Following Inhalation of Transuranic Compounds.- Lung Irradiation with Static Plutonium Microspheres.- Respiratory Carcinogenesis in Rats after Inhalation of Radioactive Aerosols of Actinides and Lanthanides in Various Physicochemical Forms.- Pulmonary Carcinogenesis and Chronic Beta Irradiation of Lung.- Histologic Observations on the Pathogenesis of Lung Cancer in Hamsters Following Administration of Polonium-210.- Cellular Localization of Intratracheally Administered 210Po in the Hamster Lung Using Autoradiography of Thin Sections from Plastic Embedded Tissue.- Experimental Respiratory Carcinogenesis: Interaction between Alpha Radiation and Benzo(a)pyrene in the Hamster.- Session V In vitro Bioassays of Respiratory Carcinogens. Chairman: M.B. SPORN.- Review and Introductory Remarks: The Role of Organ Culture and Cell Culture Methods in Studies of Respiratory Carcinogenesis and Anti-Carcinogenesis.- Interactions between Radiation and Benzo(a)pyrene in an in vitro Model for Malignant Transformation.- Dose Dependence of Carcinogen-Induced Changes in Tracheal Epithelium in Organ Culture.- Topical Application of Polycyclic Hydrocarbons to Differentiated Respiratory Epithelium in Long-Term Organ Cultures.- The Bioassay of Carcinogenesis: Effects on the Epithelial Cell Complement of Rat Tracheae Maintained in vitro.- Effects of Cigarette Smoke Condensate (CSC) on RatFetal Lung in Organ Culture.- Tracheal Grafts.- Studies of Ultrastructure, Cytochemistry, and Organ Culture of Human Bronchial Epithelium.- Studies on Carcinogen Binding in vitro in Isolated Hamster Tracheas.- The Reversal of Keratinized Squamous Metaplastic Lesions of Vitamin A Deficiency in Tracheobronchial Epithelium by Vitamin A and Vitamin A Analogs in Organ Culture: A Model System for Anti-Carcinogenesis Studies.- Transformation of Nonvirus Producing BALB/3T3 Cells by an Environmental Extract.- Concluding Remarks: Progress in Respiratory Carcinogenesis Bioassays.- List of Contributors.
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