List of Contributors vii Preface xi 1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1 Gene Discovery 2 Delineating Additional Risk Factors 13 3 Data Collection: Next Steps in Psychiatric Genetics 39 4 Environmental Risk and Gene-Environment Relationships in Psychiatric Disorders 51 Understanding Rare Variation 5 Rare Variants: Shared Paths for Therapeutic Development and Neurobiological Investigation 69 6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental Disorders 103 7 Experimental Model Systems for Rare and Common Variants 117 Understanding Common Variation 8 Common Alleles: Next Steps in the Study of Common Variants 131 9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders 155 10 From Common Variant to Function: State-of-the-Art Approaches 167 11 Contextualizing Convergent Common Variant Mechanisms through Systems Biology 179 Clinical Considerations 12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201 13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities and Obstacles 219 14 Ethical Challenges Associated with Advances in Genetic Prediction of Neuropsychiatric Disorders 237 15 Psychiatric Genetic Counseling: Next Steps 249 16 Concluding Summary 261 Bibliography 267 Subject Index 319 Strungmann Forum Report Series 325
List of Contributors vii Preface xi 1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1 Gene Discovery 2 Delineating Additional Risk Factors 13 3 Data Collection: Next Steps in Psychiatric Genetics 39 4 Environmental Risk and Gene-Environment Relationships in Psychiatric Disorders 51 Understanding Rare Variation 5 Rare Variants: Shared Paths for Therapeutic Development and Neurobiological Investigation 69 6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental Disorders 103 7 Experimental Model Systems for Rare and Common Variants 117 Understanding Common Variation 8 Common Alleles: Next Steps in the Study of Common Variants 131 9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders 155 10 From Common Variant to Function: State-of-the-Art Approaches 167 11 Contextualizing Convergent Common Variant Mechanisms through Systems Biology 179 Clinical Considerations 12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201 13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities and Obstacles 219 14 Ethical Challenges Associated with Advances in Genetic Prediction of Neuropsychiatric Disorders 237 15 Psychiatric Genetic Counseling: Next Steps 249 16 Concluding Summary 261 Bibliography 267 Subject Index 319 Strungmann Forum Report Series 325
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