Exploring and Exploiting Genetic Risk for Psychiatric Disorders
Herausgeber: Binder, Elisabeth; Gordon, Joshua A.
Exploring and Exploiting Genetic Risk for Psychiatric Disorders
Herausgeber: Binder, Elisabeth; Gordon, Joshua A.
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"This volume examines the state of psychiatric genetics and charts a path forward for further discovery and translation"--
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"This volume examines the state of psychiatric genetics and charts a path forward for further discovery and translation"--
Produktdetails
- Produktdetails
- Strungmann Forum Reports
- Verlag: MIT Press Ltd
- Seitenzahl: 340
- Erscheinungstermin: 10. Oktober 2023
- Englisch
- Abmessung: 152mm x 229mm x 22mm
- Gewicht: 454g
- ISBN-13: 9780262547383
- ISBN-10: 0262547384
- Artikelnr.: 68271115
- Strungmann Forum Reports
- Verlag: MIT Press Ltd
- Seitenzahl: 340
- Erscheinungstermin: 10. Oktober 2023
- Englisch
- Abmessung: 152mm x 229mm x 22mm
- Gewicht: 454g
- ISBN-13: 9780262547383
- ISBN-10: 0262547384
- Artikelnr.: 68271115
edited Joshua A. Gordon and Elisabeth B. Binder
List of Contributors vii
Preface xi
1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1
Gene Discovery
2 Delineating Additional Risk Factors 13
3 Data Collection: Next Steps in Psychiatric Genetics 39
4 Environmental Risk and Gene-Environment Relationships in Psychiatric
Disorders 51
Understanding Rare Variation
5 Rare Variants: Shared Paths for Therapeutic Development and
Neurobiological Investigation 69
6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental
Disorders 103
7 Experimental Model Systems for Rare and Common Variants 117
Understanding Common Variation
8 Common Alleles: Next Steps in the Study of Common Variants 131
9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders
155
10 From Common Variant to Function: State-of-the-Art Approaches 167
11 Contextualizing Convergent Common Variant Mechanisms through Systems
Biology 179
Clinical Considerations
12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201
13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities
and Obstacles 219
14 Ethical Challenges Associated with Advances in Genetic Prediction of
Neuropsychiatric Disorders 237
15 Psychiatric Genetic Counseling: Next Steps 249
16 Concluding Summary 261
Bibliography 267
Subject Index 319
Strungmann Forum Report Series 325
Preface xi
1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1
Gene Discovery
2 Delineating Additional Risk Factors 13
3 Data Collection: Next Steps in Psychiatric Genetics 39
4 Environmental Risk and Gene-Environment Relationships in Psychiatric
Disorders 51
Understanding Rare Variation
5 Rare Variants: Shared Paths for Therapeutic Development and
Neurobiological Investigation 69
6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental
Disorders 103
7 Experimental Model Systems for Rare and Common Variants 117
Understanding Common Variation
8 Common Alleles: Next Steps in the Study of Common Variants 131
9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders
155
10 From Common Variant to Function: State-of-the-Art Approaches 167
11 Contextualizing Convergent Common Variant Mechanisms through Systems
Biology 179
Clinical Considerations
12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201
13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities
and Obstacles 219
14 Ethical Challenges Associated with Advances in Genetic Prediction of
Neuropsychiatric Disorders 237
15 Psychiatric Genetic Counseling: Next Steps 249
16 Concluding Summary 261
Bibliography 267
Subject Index 319
Strungmann Forum Report Series 325
List of Contributors vii
Preface xi
1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1
Gene Discovery
2 Delineating Additional Risk Factors 13
3 Data Collection: Next Steps in Psychiatric Genetics 39
4 Environmental Risk and Gene-Environment Relationships in Psychiatric
Disorders 51
Understanding Rare Variation
5 Rare Variants: Shared Paths for Therapeutic Development and
Neurobiological Investigation 69
6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental
Disorders 103
7 Experimental Model Systems for Rare and Common Variants 117
Understanding Common Variation
8 Common Alleles: Next Steps in the Study of Common Variants 131
9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders
155
10 From Common Variant to Function: State-of-the-Art Approaches 167
11 Contextualizing Convergent Common Variant Mechanisms through Systems
Biology 179
Clinical Considerations
12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201
13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities
and Obstacles 219
14 Ethical Challenges Associated with Advances in Genetic Prediction of
Neuropsychiatric Disorders 237
15 Psychiatric Genetic Counseling: Next Steps 249
16 Concluding Summary 261
Bibliography 267
Subject Index 319
Strungmann Forum Report Series 325
Preface xi
1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1
Gene Discovery
2 Delineating Additional Risk Factors 13
3 Data Collection: Next Steps in Psychiatric Genetics 39
4 Environmental Risk and Gene-Environment Relationships in Psychiatric
Disorders 51
Understanding Rare Variation
5 Rare Variants: Shared Paths for Therapeutic Development and
Neurobiological Investigation 69
6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental
Disorders 103
7 Experimental Model Systems for Rare and Common Variants 117
Understanding Common Variation
8 Common Alleles: Next Steps in the Study of Common Variants 131
9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders
155
10 From Common Variant to Function: State-of-the-Art Approaches 167
11 Contextualizing Convergent Common Variant Mechanisms through Systems
Biology 179
Clinical Considerations
12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201
13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities
and Obstacles 219
14 Ethical Challenges Associated with Advances in Genetic Prediction of
Neuropsychiatric Disorders 237
15 Psychiatric Genetic Counseling: Next Steps 249
16 Concluding Summary 261
Bibliography 267
Subject Index 319
Strungmann Forum Report Series 325