Rajeev Kharb

Exploring Privileged Heterocyclic Scaffolds:

Their Scope as Novel Anti-Inflammatory Drug Candidates

• Broschiertes Buch

Produktbeschreibung

Inflammation is characterized by redness, heat, swelling, pain and sometimes loss of function of tissues. Cyclooxygenases (COXs) are mainly responsible for inflammation. Constitutive COX-1 is responsible for providing cytoprotection in gastrointestinal (GI) tract whereas inducible COX-2 facilitates inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat the signs and symptoms of inflammation. Traditional non-steroidal anti-inflammatory drugs (NSAIDs) such as Aspirin, Diclofenac, Flurbiprofen and Ibuprofen act via the inhibition of the COX-1 isoenzyme or the combined inhibition of COX-1 and COX-2 isoenzymes. However they show greater selectivity for COX-1 than COX-2 as well as produce serious side effect like hepatic toxicity. Therefore, it is urgently required to identify new targets that are essential for the design and development of novel anti-inflammatory agents as an alternative to NSAIDs. The relevant information provided in this manuscript canbe found useful for drug design of novel anti-inflammatory agents having greater safety, selectivity and potency as well as lesser side effects.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 88
• Erscheinungstermin: 17. August 2018
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 149g
• ISBN-13: 9786139900893
• ISBN-10: 6139900891
• Artikelnr.: 53880546

Autorenporträt

El Dr. Rajeev Kharb trabaja actualmente como profesor asociado en el Instituto de Farmacia Amity, Universidad Amity de Uttar Pradesh, Noida, India. Tiene una experiencia docente y de investigación de 16,5 años. El autor ha publicado 40 artículos de revisión y de investigación y ha escrito 4 libros. Su área de investigación incluye la síntesis de compuestos heterocíclicos.