Mihriban Karaayvaz

Exploring the Role of miRNAs in Human Cancer

microRNAs in Cancer: Translation of biology into clinical application

• Broschiertes Buch

Produktbeschreibung

Unraveling the role of microRNAs in cancer has gained growing interest in the last few years. In this study, we identified miR-215 as a potential prognostic biomarker and miR-129 as a potential tumor suppressor and a novel therapeutic target in colorectal cancer. We showed that miR-215 levels were significantly decreased in tumors compared with corresponding normal tissues in patients diagnosed with stage II or stage III colorectal cancer. Furthermore, we described a novel mechanism mediated by miR-129 to trigger apoptosis by suppressing a key anti-apoptotic protein, BCL2. The expression of miR-129 was significantly and progressively down regulated in colorectal cancer tissue specimens compared with the adenomas and normal control samples. More importantly, we demonstrated that miR-129 increased the cytotoxic effect of 5- fluorouracil, in vitro and in vivo. We expect that our findings will provide a better insight into the role of microRNAs in cancer and will allow us to carry these molecules into clinical application.

Produktdetails

• Verlag: Scholar's Press
• Seitenzahl: 164
• Erscheinungstermin: 24. November 2013
• Englisch
• Abmessung: 220mm x 150mm x 10mm
• Gewicht: 262g
• ISBN-13: 9783639703993
• ISBN-10: 3639703995
• Artikelnr.: 40035435

Autorenporträt

I received my PhD from Stony Brook University in 2013. I published six manuscripts, including four first-author articles in graduate school, focusing on mechanisms of tumor cell survival and its influence on cancer natural history and prognosis. Currently, I work as a research fellow at the MGH Cancer Center and Harvard Medical School.