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The aim of this book is to collect breakthrough papers focusing on data supporting the view that extracellular chaperones and their related miRNA (including either those in their soluble form or those hosted in extracellular vesicles) may represent an innovative diagnostic tool in many chronic human pathologies. We will particularly focus on papers that-other than presenting solid data on the aforementioned aim-also discuss original data about mechanistic roles of these molecules inside and outside cells.