Extracellular Matrix Rigidity Sensing and Cellular Response - Kostic, Ana
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This book focuses on matrix rigidity responses in neurons and fibroblasts. The specific matrix rigidity requirements in different cell types have been correlated to the rigidities of their native tissues in vivo. While fibroblasts spread to the larger areas on rigid than on soft substrates, soft substrates stimulate axon elongation and branching in the primary neurons. In our studies, we described a fibronectin-specific rigidity response pathway, present both in fibroblasts and neurons. Although neurons respond to the FN rigidity in the opposite way to fibroblasts, we suggest that the…mehr

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Produktbeschreibung
This book focuses on matrix rigidity responses in neurons and fibroblasts. The specific matrix rigidity requirements in different cell types have been correlated to the rigidities of their native tissues in vivo. While fibroblasts spread to the larger areas on rigid than on soft substrates, soft substrates stimulate axon elongation and branching in the primary neurons. In our studies, we described a fibronectin-specific rigidity response pathway, present both in fibroblasts and neurons. Although neurons respond to the FN rigidity in the opposite way to fibroblasts, we suggest that the mechanism of detecting FN rigidity is similar and involves rigidity-dependent RPTP_ recruitment of Fyn, and subsequent p130Cas tyrosine phosphorylation. Once phosphorylated, p130Cas could signal to a variety of different pathways that normally promote growth and not differentiation.
Autorenporträt
Ana Kostic graduated as Valedictorian from University of Belgrade with a double major in Molecular Biology and Physiology. She holds a PhD degree from Columbia University, New York. Dr. Kostic currently works as Associate Director of Predictive Medicine at Regeneron Pharmaceuticals, Inc. She lives in New York City.