Extrusion-Spheronization VS Solution / Suspension Layering Technique - Kulshrestha, Prateek
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Purpose: The purpose of this study is to formulate itopride hydrochloride sustained release pellets by Extrusion-Spheronization and Solution/ Suspension layering technique and to compare the pellet characteristics prepared from both the techniques. Methods: In the Extrusion-Spheronization technique, the drug pellets were prepared by mixing the drug with excipients along with a binder solution, the resultant mass was extruded through extruder followed by spheronizer. In Solution/suspension layering technology the pellets were prepared by coating the drug solution/suspension on the sugar spheres…mehr

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Produktbeschreibung
Purpose: The purpose of this study is to formulate itopride hydrochloride sustained release pellets by Extrusion-Spheronization and Solution/ Suspension layering technique and to compare the pellet characteristics prepared from both the techniques. Methods: In the Extrusion-Spheronization technique, the drug pellets were prepared by mixing the drug with excipients along with a binder solution, the resultant mass was extruded through extruder followed by spheronizer. In Solution/suspension layering technology the pellets were prepared by coating the drug solution/suspension on the sugar spheres in a fluidized bed processor (FBP). The prepared drug pellets from both the techniques were seal coated with HPMC 5cps followed by sustained release coating of Ethyl cellulose 7cps in the FBP.
Autorenporträt
Prateek Kulshrestha tem um Mestrado em Farmácia e fez poucos projectos de investigação durante o seu curso de estudo. Trabalha agora como Associado para Assuntos Regulamentares numa empresa líder em ciências da vida.