Fabrication And Evaluation Of Transdermal Systems Containing Antihypertensive Agents

Fabrication And Evaluation Of Transdermal Systems Containing Antihypertensive Agents

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The aim of the present investigation was to develop and characterize transdermal matrix patch of Lercanidipine hydrochloride and Diltiazem hydrochloride for controlled drug delivery by the solvent evaporation method. To achieve controlled drug release, polymers such as psyllium and HPMC K15M were optimized. Moreover, the skin permeation effect of essential oils such as linseed oil, jojoba oil and pumpkin seed oil were investigated on wistar rat skin. A 32 full factorial design applied to optimize two formulation variables: concentration of essential oil as a permeation enhancer and polymer fix...