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This guidance note provides insights on enhancing trade facilitation to strengthen responses to the current pandemic and future health emergencies. COVID-19 has highlighted the need for new investments and reforms to prepare for future pandemics and other crises. Timely, accurate information is required to support national and international responses. This guidance note aims to help build a shared framework for understanding trade facilitation and border health issues in the context of the COVID-19 pandemic. It discusses effective manufacturing supply chains and equal vaccine distribution, the efficient flow of vaccines and medical goods across borders, and funding modalities for trade facilitation and regional public goods.